Literature DB >> 17805698

The metabolism of C(14)-alpha-tocopheryl quinone and C(14)-alpha-tocopheryl hydroquinone.

C K Chow1, H H Draper, A S Csallany, M Chiu.   

Abstract

The metabolism of C(14)-d-alpha-tocopheryl quinone (alpha-TQ) and its hydroquinone (alphaTHQ) was investigated. Forty-six hours after intraperitoneal administration of either compound to rats the radioactivity isolated from the liver was present almost exclusively in C(14)-alpha-TQ. The results indicated, however, that in situ this compound was present primarily in the reduced form. No conversion to C(14)-alpha-tocopherol or other liver metabolites was observed. alpha-THQ was eliminated from the tissues more rapidly than alpha-TQ. The main metabolite excreted in the urine was a conjugate of alpha-tocopheronic acid and the main metabolite excreted in the feces was a conjugate of alpha-TQ. Free C(14)-alpha-TQ was present in the feces after administration of this compound but not after C(14)-alpha-THQ administration.

Entities:  

Year:  1967        PMID： 17805698     DOI： 10.1007/BF02531852

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  16 in total

1.  THE VITAMIN E ACTIVITY OF ALPHA-TOCOPHERYLQUINONE AND ALPHA-TOCOPHERYLHYDROQUINONE IN THE RAT.

Authors:  J BUNYAN; D MCHALE; J GREEN
Journal:  Br J Nutr       Date:  1963       Impact factor: 3.718

2.  Pyridine nucleotide-to copheronolactone reductase.

Authors:  J BUNYAN; J GREEN; A T DIPLOCK; E E EDWIN
Journal:  Biochim Biophys Acta       Date:  1961-05-13

3.  METABOLIC PRODUCTS OF ALPHA-TOCOPHEROL IN THE LIVERS OF RATS GIVEN INTRAPERITONEAL INJECTIONS OF (14C)-ALPHA-TOCOPHEROL.

Authors:  P A PLACK; J G BIERI
Journal:  Biochim Biophys Acta       Date:  1964-12-02

4.  The effect of alpha-tocopherol, alpha-tocopherylhydroquinone and their esters on experimental muscular dystrophy in the rat.

Authors:  J B MACKENZIE; C G MACKENZIE
Journal:  J Nutr       Date:  1959-02-10       Impact factor: 4.798

5.  Dimerization of alpha-tocopherol in vivo.

Authors:  A S CSALLANY; H H DRAPER
Journal:  Arch Biochem Biophys       Date:  1963-02       Impact factor: 4.013

6.  Spectrofluorometric determination of tocopherols.

Authors:  D E DUGGAN
Journal:  Arch Biochem Biophys       Date:  1959-09       Impact factor: 4.013

7.  Action of N, N'-diphenyl-p-phenylenediamine in tocopherol deficiency diseases.

Authors:  H H DRAPER; A S CSALLANY
Journal:  Proc Soc Exp Biol Med       Date:  1958-12

8.  The metabolism of vitamin E. II. Purification and characterization of urinary metabolites of alpha-tocopherol.

Authors:  A EISENGART; A T MILHORAT; E J SIMON; L SUNDHEIM
Journal:  J Biol Chem       Date:  1956-08       Impact factor: 5.157

9.  Vitamin E activity of alpha-tocopherylhydroquinone and muscular dystrophy.

Authors:  J B MACKENZIE; C G MACKENZIE
Journal:  Proc Soc Exp Biol Med       Date:  1953-11

10.  [Formation of tocopheronlactone from apha-tocopherylquinone in the human organism].

Authors:  H Schmandke
Journal:  Int Z Vitaminforsch       Date:  1965
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  2 in total

1.  Sensitive fluorometric method for tissue tocopherol analysis.

Authors:  S L Taylor; M P Lamden; A L Tappel
Journal:  Lipids       Date:  1976-07       Impact factor: 1.880

2.  On the occurrence of alpha-tocopherolquinone in rat tissue.

Authors:  J G Bieri; T J Tolliver
Journal:  Lipids       Date:  1981-10       Impact factor: 1.880
  2 in total

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