| Literature DB >> 1778755 |
T Yamane1, N Hagiwara, M Tateishi, S Akachi, M Kim, J Okuzumi, Y Kitao, M Inagake, K Kuwata, T Takahashi.
Abstract
The effect of green tea polyphenol fraction (GTP) on azoxymethane(AOM)-induced colon carcinogenesis was investigated in male Fischer rats. The rats were given AOM (7.4 mg/kg body weight) s.c. once a week for 10 weeks. A week after the treatment, they were divided into three groups: AOM-control (26 rats), AOM-GTP1 (26 rats) and AOM-GTP2 (25 rats). AOM-GTP1 and AOM-GTP2 groups respectively received 0.01 and 0.1% GTP in drinking water from week 11 to 26. AOM-control group received tap water throughout this experiment. Autopsy on week 26 showed that tumor incidence and average numbers of tumors per rat in the AOM-GTP1 and AOM-GTP2 groups were significantly lower than those of the AOM-control group: 38.1% and 47.6% versus 77.3%; 0.6 and 0.7 versus 1.5. Thus, it was concluded that GTP inhibited the development of AOM-induced colon carcinogenesis. The inhibition by GTP did not show significant dose dependence.Entities:
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Year: 1991 PMID： 1778755 PMCID： PMC5918351 DOI： 10.1111/j.1349-7006.1991.tb01801.x
Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050