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Literature DB >> 2503469

Inhibitory effect of (-)-epigallocatechin gallate on carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine in mouse duodenum.

Y Fujita¹, T Yamane, M Tanaka, K Kuwata, J Okuzumi, T Takahashi, H Fujiki, T Okuda.

Abstract

(-)-Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of green tea infusion and inhibits tumor promotion by teleocidin in two-stage carcinogenesis on mouse skin. In this work, EGCG was found to inhibit tumor promotion in the gastrointestinal tract in a model system of mouse duodenal carcinogenesis with N-ethyl-N'-nitro-N-nitrosoguanidine. The duodenal tumors that developed were studied stereomicroscopically and histologically.

Entities: Chemical Disease Species

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Year: 1989 PMID： 2503469 PMCID： PMC5917795 DOI： 10.1111/j.1349-7006.1989.tb01666.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

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