Literature DB >> 17785512

Effects of serum on in vitro susceptibility testing of echinocandins.

Zekaver Odabasi1, Victor Paetznick, John H Rex, Luis Ostrosky-Zeichner.   

Abstract

The effects of protein binding on the activities of caspofungin, anidulafungin, and micafungin were evaluated against Candida and Aspergillus species. Adding human serum sharply increased the MICs of micafungin and anidulafungin and modestly affected the MIC of caspofungin. The increase in MICs does not appear consistent with the rate of protein binding for the three compounds.

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Year:  2007        PMID： 17785512      PMCID： PMC2151461          DOI： 10.1128/AAC.01589-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Influence of albumin on itraconazole and ketoconazole antifungal activity: results of a dynamic in vitro study.

Authors:  M Schäfer-Korting; H C Korting; F Amann; R Peuser; A Lukacs
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

2.  Influence of plasma protein binding on the brain uptake of an antifungal agent, terbinafine, in rats.

Authors:  B Machard; P Misslin; M Lemaire
Journal:  J Pharm Pharmacol       Date:  1989-10       Impact factor: 3.765

3.  The relevance of pharmacokinetics to in-vitro models: protein binding--does it matter?

Authors:  R Wise
Journal:  J Antimicrob Chemother       Date:  1985-01       Impact factor: 5.790

4.  Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872).

Authors:  R Hajdu; R Thompson; J G Sundelof; B A Pelak; F A Bouffard; J F Dropinski; H Kropp
Journal:  Antimicrob Agents Chemother       Date:  1997-11       Impact factor: 5.191

5.  In vitro activity of micafungin (FK-463) against Candida spp.: microdilution, time-kill, and postantifungal-effect studies.

Authors:  Erika J Ernst; Ellen E Roling; C Rosemarie Petzold; Douglas J Keele; Michael E Klepser
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

6.  Quality control limits for broth microdilution susceptibility tests of ten antifungal agents.

Authors:  A L Barry; M A Pfaller; S D Brown; A Espinel-Ingroff; M A Ghannoum; C Knapp; R P Rennie; J H Rex; M G Rinaldi
Journal:  J Clin Microbiol       Date:  2000-09       Impact factor: 5.948

7.  Inactivity of terbinafine in a rat model of pulmonary aspergillosis.

Authors:  H J Schmitt; J Andrade; F Edwards; Y Niki; E Bernard; D Armstrong
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1990-11       Impact factor: 3.267

8.  Influence of human sera on the in vitro activity of the echinocandin caspofungin (MK-0991) against Aspergillus fumigatus.

Authors:  T Chiller; K Farrokhshad; E Brummer; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

9.  In vitro activities of a new lipopeptide antifungal agent, FK463, against a variety of clinically important fungi.

Authors:  S Tawara; F Ikeda; K Maki; Y Morishita; K Otomo; N Teratani; T Goto; M Tomishima; H Ohki; A Yamada; K Kawabata; H Takasugi; K Sakane; H Tanaka; F Matsumoto; S Kuwahara
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

10.  Interaction of terbinafine with human serum and serum proteins.

Authors:  N S Ryder; I Frank
Journal:  J Med Vet Mycol       Date:  1992
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  39 in total

1.  Breakthrough invasive candidiasis in patients on micafungin.

Authors:  Christopher D Pfeiffer; Guillermo Garcia-Effron; Aimee K Zaas; John R Perfect; David S Perlin; Barbara D Alexander
Journal:  J Clin Microbiol       Date:  2010-04-26       Impact factor: 5.948

2.  Albumin Enhances Caspofungin Activity against Aspergillus Species by Facilitating Drug Delivery to Germinating Hyphae.

Authors:  Petros Ioannou; Aggeliki Andrianaki; Tonia Akoumianaki; Irene Kyrmizi; Nathaniel Albert; David Perlin; George Samonis; Dimitrios P Kontoyiannis; Georgios Chamilos
Journal:  Antimicrob Agents Chemother       Date:  2015-12-07       Impact factor: 5.191

3.  In vitro activities of various antifungal drugs against Aspergillus terreus: Global assessment using the methodology of the European committee on antimicrobial susceptibility testing.

Authors:  Cornelia Lass-Flörl; Ana Alastruey-Izquierdo; Manuel Cuenca-Estrella; Susanne Perkhofer; Juan Luis Rodriguez-Tudela
Journal:  Antimicrob Agents Chemother       Date:  2008-12-08       Impact factor: 5.191

4.  Bronchopulmonary disposition of micafungin in healthy adult volunteers.

Authors:  Anthony M Nicasio; Pamela R Tessier; David P Nicolau; R Fredrick Knauft; John Russomanno; Eric Shore; Joseph L Kuti
Journal:  Antimicrob Agents Chemother       Date:  2008-12-29       Impact factor: 5.191

5.  Pneumocystis workshop: 10th anniversary summary.

Authors:  James M Beck; Melanie T Cushion
Journal:  Eukaryot Cell       Date:  2009-01-23

6.  Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates.

Authors:  Cristina Jiménez-Ortigosa; Padmaja Paderu; Mary R Motyl; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2013-12-09       Impact factor: 5.191

7.  Pyrosequencing to detect mutations in FKS1 that confer reduced echinocandin susceptibility in Candida albicans.

Authors:  Nathan P Wiederhold; Jodi L Grabinski; Guillermo Garcia-Effron; David S Perlin; Samuel A Lee
Journal:  Antimicrob Agents Chemother       Date:  2008-09-15       Impact factor: 5.191

8.  Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints.

Authors:  M A Pfaller; D J Diekema; L Ostrosky-Zeichner; J H Rex; B D Alexander; D Andes; S D Brown; V Chaturvedi; M A Ghannoum; C C Knapp; D J Sheehan; T J Walsh
Journal:  J Clin Microbiol       Date:  2008-06-25       Impact factor: 5.948

9.  Antifungal activity of micafungin in serum.

Authors:  Jun Ishikawa; Tetsuo Maeda; Itaru Matsumura; Masato Yasumi; Hidetoshi Ujiie; Hiroaki Masaie; Tsuyoshi Nakazawa; Nobuo Mochizuki; Satoshi Kishino; Yuzuru Kanakura
Journal:  Antimicrob Agents Chemother       Date:  2009-08-17       Impact factor: 5.191

10.  Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints.

Authors:  Guillermo Garcia-Effron; Steven Park; David S Perlin
Journal:  Antimicrob Agents Chemother       Date:  2008-10-27       Impact factor: 5.191
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