Literature DB >> 1778181

The steroid hormone antagonist RU486. Mechanism at the cellular level and clinical applications.

E E Baulieu1.   

Abstract

The cellular and molecular mechanism of RU486, a steroid hormone antagonist, is discussed in detail. Principally, RU486 opposes the action of two types of hormones: progesterone and glucocorticosteroids. The clinical applications are also described, as well as the future outlook.

Entities:  

Keywords:  Adrenal Cortex Effects; Adrenal Cortex Hormones; Biology; Corpus Luteum; Cytologic Effects; Developed Countries; Diseases; Endocrine Effects; Endocrine System; Europe; France; Genitalia; Genitalia, Female; Hormone Antagonists; Hormone Receptors; Hormones; Literature Review; Luteolytic Effects; Mediterranean Countries; Membrane Proteins; Neoplasms; Ovary; Physiology; Progestational Hormones; Progesterone; Ru-486--pharmacodynamics; Urogenital System; Western Europe

Mesh：

Substances：

Year:  1991        PMID： 1778181

Source DB:  PubMed          Journal:  Endocrinol Metab Clin North Am        ISSN： 0889-8529            Impact factor:   4.741


  9 in total

Review 1.  The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling.

Authors:  Michael J Large; Francesco J DeMayo
Journal:  Mol Cell Endocrinol       Date:  2011-07-28       Impact factor: 4.102

2.  Glucocorticoid treatment of astrocytes results in temporally dynamic transcriptome regulation and astrocyte-enriched mRNA changes in vitro.

Authors:  Bradley S Carter; Fan Meng; Robert C Thompson
Journal:  Physiol Genomics       Date:  2012-10-30       Impact factor: 3.107

3.  Prolonged pregnancy in women is associated with attenuated myometrial expression of progesterone receptor co-regulator Krüppel-like Factor 9.

Authors:  John Mark P Pabona; Daying Zhang; David S Ginsburg; Frank A Simmen; Rosalia C M Simmen
Journal:  J Clin Endocrinol Metab       Date:  2015-01       Impact factor: 5.958

4.  Progesterone directly and rapidly inhibits GnRH neuronal activity via progesterone receptor membrane component 1.

Authors:  Nicholas Michael Bashour; Susan Wray
Journal:  Endocrinology       Date:  2012-07-20       Impact factor: 4.736

5.  Specific activation of the glucocorticoid receptor and modulation of signal transduction pathways in human lens epithelial cells.

Authors:  Vanita Gupta; Niranjan Awasthi; B J Wagner
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-04       Impact factor: 4.799

6.  Selective effects of 8-Br-cAMP on agonists and antagonists of the glucocorticoid receptor.

Authors:  S Zhang; M Danielsen
Journal:  Endocrine       Date:  1995-01       Impact factor: 3.633

7.  Comparison of the effects of estradiol and progesterone on serotonergic function.

Authors:  Saloua Benmansour; Rami S Weaver; Amanda K Barton; Opeyemi S Adeniji; Alan Frazer
Journal:  Biol Psychiatry       Date:  2012-01-05       Impact factor: 13.382

8.  Glucocorticoid activation of chromogranin A gene expression. Identification and characterization of a novel glucocorticoid response element.

Authors:  D J Rozansky; H Wu; K Tang; R J Parmer; D T O'Connor
Journal:  J Clin Invest       Date:  1994-12       Impact factor: 14.808

9.  Treatment of a Woman with Inoperable Meningioma Using Mifepristone for 26 Years.

Authors:  Maria das Dores Medina-Lopes; Luiz Augusto Casulari
Journal:  Case Rep Neurol Med       Date:  2020-02-11
  9 in total

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