Literature DB >> 17768168

Laser-driven proton oncology--a unique new cancer therapy?

K W D Ledingham1, W Galster, R Sauerbrey.   

Abstract

In 2000, the University of Strathclyde, collaborating with the Rutherford Appleton Laboratory, organized the first workshop dealing with the potential of high-power laser technology in medicine. Two areas of potential were identified: firstly the production of positron emission tomography (PET) isotopes; and secondly, the potential for laser-accelerated proton and heavy ion beams for therapy. The attendees, mainly clinicians and radiation physicists, emphasised that the laser community should concentrate on developing laser and target technology for therapy rather than isotope production because of the potential advantages over conventional accelerator technology for that purpose. On the 30 March 2007, the universities of Strathclyde and Paisley organized a follow-up meeting to identify the progress made in laser-driven proton and ion beam technology with applications leading to proton and ion beam therapy for deep-seated tumours. The meeting was supported by the Scottish Universities Physics Alliance (SUPA)--an organization set up in Scotland to bring together all of the physics departments collaborating with life scientists to work on ground-breaking new science which no single university could attempt. This is a summary of the meeting.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 17768168     DOI: 10.1259/bjr/29504942

Source DB:  PubMed          Journal:  Br J Radiol        ISSN: 0007-1285            Impact factor:   3.039


  7 in total

1.  Induction and repair of DNA double-strand breaks assessed by gamma-H2AX foci after irradiation with pulsed or continuous proton beams.

Authors:  O Zlobinskaya; G Dollinger; D Michalski; V Hable; C Greubel; G Du; G Multhoff; B Röper; M Molls; T E Schmid
Journal:  Radiat Environ Biophys       Date:  2012-01-07       Impact factor: 1.925

2.  Radiobiological influence of megavoltage electron pulses of ultra-high pulse dose rate on normal tissue cells.

Authors:  Lydia Laschinsky; Leonhard Karsch; Elisabeth Leßmann; Melanie Oppelt; Jörg Pawelke; Christian Richter; Michael Schürer; Elke Beyreuther
Journal:  Radiat Environ Biophys       Date:  2016-05-19       Impact factor: 1.925

3.  Comparison study of in vivo dose response to laser-driven versus conventional electron beam.

Authors:  Melanie Oppelt; Michael Baumann; Ralf Bergmann; Elke Beyreuther; Kerstin Brüchner; Josefin Hartmann; Leonhard Karsch; Mechthild Krause; Lydia Laschinsky; Elisabeth Leßmann; Maria Nicolai; Maria Reuter; Christian Richter; Alexander Sävert; Michael Schnell; Michael Schürer; Julia Woithe; Malte Kaluza; Jörg Pawelke
Journal:  Radiat Environ Biophys       Date:  2015-01-20       Impact factor: 1.925

4.  Efficient post-acceleration of protons in helical coil targets driven by sub-ps laser pulses.

Authors:  H Ahmed; S Kar; G Cantono; P Hadjisolomou; A Poye; D Gwynne; C L S Lewis; A Macchi; K Naughton; G Nersisyan; V Tikhonchuk; O Willi; M Borghesi
Journal:  Sci Rep       Date:  2017-09-07       Impact factor: 4.379

5.  An optimized small animal tumour model for experimentation with low energy protons.

Authors:  Elke Beyreuther; Kerstin Brüchner; Mechthild Krause; Margret Schmidt; Rita Szabo; Jörg Pawelke
Journal:  PLoS One       Date:  2017-05-18       Impact factor: 3.240

6.  DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates.

Authors:  F Hanton; P Chaudhary; D Doria; D Gwynne; C Maiorino; C Scullion; H Ahmed; T Marshall; K Naughton; L Romagnani; S Kar; G Schettino; P McKenna; S Botchway; D R Symes; P P Rajeev; K M Prise; M Borghesi
Journal:  Sci Rep       Date:  2019-03-14       Impact factor: 4.379

7.  Establishment of a small animal tumour model for in vivo studies with low energy laser accelerated particles.

Authors:  Kerstin Brüchner; Elke Beyreuther; Michael Baumann; Mechthild Krause; Melanie Oppelt; Jörg Pawelke
Journal:  Radiat Oncol       Date:  2014-02-18       Impact factor: 3.481

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.