Literature DB >> 17768052

Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents.

Aman Mahajan1, Susan Yeh, Margo Nell, Constance E J van Rensburg, Kelly Chibale.   

Abstract

New 7-chloroquinolinyl thiourea derivatives derived from the corresponding 4,7-dichloroquinoline isothiocyanate were synthesized and evaluated for in vitro antimalarial and anticancer activity. The most active compound from the series displayed an inhibitory IC(50) value of 1.2 microM against the D10 strain of Plasmodium falciparum. Lack of cytotoxicity towards HeLa cells indicates selectivity towards parasites.

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Year:  2007        PMID： 17768052     DOI： 10.1016/j.bmcl.2007.07.049

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas.

Authors:  Kekeli Ekoue-Kovi; Kimberly Yearick; Daniel P Iwaniuk; Jayakumar K Natarajan; John Alumasa; Angel C de Dios; Paul D Roepe; Christian Wolf
Journal:  Bioorg Med Chem       Date:  2008-11-12       Impact factor: 3.641

2.  Synthesis, X-ray crystal structure elucidation and Hirshfeld surface analysis of N-((4-(1H-benzo[d]imidazole-2-yl)phenyl)carbamothioyl)benzamide: investigations for elastase inhibition, antioxidant and DNA binding potentials for biological applications.

Authors:  Nasima Arshad; Mamoona Rafiq; Rabail Ujan; Aamer Saeed; Shahid I Farooqi; Fouzia Perveen; Pervaiz Ali Channar; Saba Ashraf; Qamar Abbas; Ashfaq Ahmed; Tuncer Hokelek; Manpreet Kaur; Jerry P Jasinski
Journal:  RSC Adv       Date:  2020-06-02       Impact factor: 4.036

3.  Quinoline: A versatile heterocyclic.

Authors:  Akranth Marella; Om Prakash Tanwar; Rikta Saha; Mohammad Rahmat Ali; Sandeep Srivastava; Mymoona Akhter; Mohammad Shaquiquzzaman; Mohammad Mumtaz Alam
Journal:  Saudi Pharm J       Date:  2012-03-29       Impact factor: 4.330

4.  Structural modifications of quinoline-based antimalarial agents: Recent developments.

Authors:  Sandhya Bawa; Suresh Kumar; Sushma Drabu; Rajiv Kumar
Journal:  J Pharm Bioallied Sci       Date:  2010-04

5.  A sustainable strategy for the synthesis of bis-2-iminothiazolidin-4-ones utilizing novel series of asymmetrically substituted bis-thioureas as viable precursors.

Authors:  Wael Abdelgayed Ahmed Arafa; Hamada Mohamed Ibrahim
Journal:  RSC Adv       Date:  2018-03-15       Impact factor: 3.361

6.  Ultrasound promoted synthesis of bis(substituted pyrazol-4-ylcarbonyl)-substituted thioureas.

Authors:  Li Xiao; Chen-Jiang Liu; Yan-Ping Li
Journal:  Molecules       Date:  2009-03-31       Impact factor: 4.411

7.  New Substituted Benzoylthiourea Derivatives: From Design to Antimicrobial Applications.

Authors:  Carmen Limban; Mariana Carmen Chifiriuc; Miron Teodor Caproiu; Florea Dumitrascu; Marilena Ferbinteanu; Lucia Pintilie; Amalia Stefaniu; Ilinca Margareta Vlad; Coralia Bleotu; Luminita Gabriela Marutescu; Diana Camelia Nuta
Journal:  Molecules       Date:  2020-03-25       Impact factor: 4.411
  7 in total

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