Yan Lu1, Zi-Dun Wang, Jing Shen, Yao-Chu Xu. 1. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
Abstract
OBJECTIVE: To evaluate the relationship between IL8-251 gene polymorphisms and gastric cancer. METHODS: Literatures were reviewed and selected based on the criteria for inclusion. The Meta-analysis software, REVMAN 4.2, was applied to check the heterogeneity across the studies and calculating the pooled OR. RESULTS: Total of 2114 cases and 2505 controls from 8 studies for IL8-251 were included. The chi(2) value was 21.48 (P = 0.003), and the pooled OR of (AA + AT) vs. TT was 1.12 (95% CI 0.90 - 1.40). Large heterogeneity was found among the studies. After the sensitivity analysis, the pooled OR of (AA + AT) vs. TT 1.21 (95% CI 1.06 - 1.39). CONCLUSION: IL8-251-A allele might be associated with higher risk of developing gastric cancer.
OBJECTIVE: To evaluate the relationship between IL8-251 gene polymorphisms and gastric cancer. METHODS: Literatures were reviewed and selected based on the criteria for inclusion. The Meta-analysis software, REVMAN 4.2, was applied to check the heterogeneity across the studies and calculating the pooled OR. RESULTS: Total of 2114 cases and 2505 controls from 8 studies for IL8-251 were included. The chi(2) value was 21.48 (P = 0.003), and the pooled OR of (AA + AT) vs. TT was 1.12 (95% CI 0.90 - 1.40). Large heterogeneity was found among the studies. After the sensitivity analysis, the pooled OR of (AA + AT) vs. TT 1.21 (95% CI 1.06 - 1.39). CONCLUSION:IL8-251-A allele might be associated with higher risk of developing gastric cancer.
Authors: Francesco Gianfagna; Emma De Feo; Cornelia M van Duijn; Gualtiero Ricciardi; Stefania Boccia Journal: Curr Genomics Date: 2008-09 Impact factor: 2.236