BACKGROUND: A bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess. AIMS: To assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life. METHOD: The experience sampling method was used to collect multiple appraisals of daily life event-related stress and negative affect in 279 female twin pairs. Cross-twin, cross-trait associations between dailylife mood bias and DSM-IV depression were conducted. RESULTS: Probands whose co-twins were diagnosed with lifetime depression showed a stronger mood bias to stress than those with co-twins without such a diagnosis, independent of probands' current depressive symptoms and to a greater extent in monozygotic twins than in dizygotic twins. CONCLUSIONS: Genetic liability to depression is in part expressed as the tendency to display negative affect in response to minor stressors in daily life. This trait may represent a true depression endophenotype.
BACKGROUND: A bias to develop negative affect in response to daily life stressors may be an important depression endophenotype, but remains difficult to assess. AIMS: To assess this mood bias endophenotype, uncontaminated by current mood, in the course of daily life. METHOD: The experience sampling method was used to collect multiple appraisals of daily life event-related stress and negative affect in 279 female twin pairs. Cross-twin, cross-trait associations between dailylife mood bias and DSM-IV depression were conducted. RESULTS: Probands whose co-twins were diagnosed with lifetime depression showed a stronger mood bias to stress than those with co-twins without such a diagnosis, independent of probands' current depressive symptoms and to a greater extent in monozygotic twins than in dizygotic twins. CONCLUSIONS: Genetic liability to depression is in part expressed as the tendency to display negative affect in response to minor stressors in daily life. This trait may represent a true depression endophenotype.
Authors: Jennifer A Margrett; Kate Daugherty; Peter Martin; Maurice MacDonald; Adam Davey; John L Woodard; L Stephen Miller; Ilene C Siegler; Leonard W Poon Journal: Aging Ment Health Date: 2011-04 Impact factor: 3.658
Authors: Jim van Os; Philippe Delespaul; Johanna Wigman; Inez Myin-Germeys; Marieke Wichers Journal: World Psychiatry Date: 2013-06 Impact factor: 49.548
Authors: Ingrid Kramer; Claudia J P Simons; Johanna T W Wigman; Dina Collip; Nele Jacobs; Catherine Derom; Evert Thiery; Jim van Os; Inez Myin-Germeys; Marieke Wichers Journal: Schizophr Bull Date: 2013-02-13 Impact factor: 9.306