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Literature DB >> 17766459

Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract.

Gillian E Gardiner¹, Mary C Rea, Brid O'Riordan, Paula O'Connor, Sheila M Morgan, Peadar G Lawlor, P Brendan Lynch, Michael Cronin, R Paul Ross, Colin Hill.

Abstract

The component peptides of lacticin 3147 were degraded by alpha-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.

Entities: Disease Species

Mesh：

Substances：

Year: 2007 PMID： 17766459 PMCID： PMC2074984 DOI： 10.1128/AEM.01117-07

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

27 in total

1. Effects of Lactococcus lactis on composition of intestinal microbiota: role of nisin.

Authors: Nete Bernbom; Tine Rask Licht; Carl-Henrik Brogren; Birthe Jelle; Anette H Johansen; Iker Badiola; Finn K Vogensen; Birgit Nørrung
Journal: Appl Environ Microbiol Date: 2006-01 Impact factor: 4.792

Review 2. Bacteriocins: developing innate immunity for food.

Authors: Paul D Cotter; Colin Hill; R Paul Ross
Journal: Nat Rev Microbiol Date: 2005-10 Impact factor: 60.633

3. Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations.

Authors: Sheila M Morgan; Paula M O'connor; Paul D Cotter; R Paul Ross; Colin Hill
Journal: Antimicrob Agents Chemother Date: 2005-07 Impact factor: 5.191

4. An application in cheddar cheese manufacture for a strain of Lactococcus lactis producing a novel broad-spectrum bacteriocin, lacticin 3147.

Authors: M P Ryan; M C Rea; C Hill; R P Ross
Journal: Appl Environ Microbiol Date: 1996-02 Impact factor: 4.792

5. Development of a lacticin 3147-enriched whey powder with inhibitory activity against foodborne pathogens.

Authors: S M Morgan; M Galvin; J Kelly; R P Ross; C Hill
Journal: J Food Prot Date: 1999-09 Impact factor: 2.077

6. Sites of organic acid production and pattern of digesta movement in the gastrointestinal tract of swine.

Authors: E T Clemens; C E Stevens; M Southworth
Journal: J Nutr Date: 1975-06 Impact factor: 4.798

7. Effects of microcin 24-producing Escherichia coli on shedding and multiple-antimicrobial resistance of Salmonella enterica serotype typhimurium in pigs.

Authors: Timothy S Frana; Steven A Carlson; Daryl C Rauser; Bradley D Jones; Brian J Fergen; Ronald W Griffith
Journal: Am J Vet Res Date: 2004-12 Impact factor: 1.156

8. Campylobacter jejuni non-culturable coccoid cells.

Authors: R R Beumer; J de Vries; F M Rombouts
Journal: Int J Food Microbiol Date: 1992 Jan-Feb Impact factor: 5.277

9. Reduction of Escherichia coli O157:H7 populations in cattle by addition of colicin E7-producing E. coli to feed.

Authors: Gerry P Schamberger; Ronald L Phillips; Jennifer L Jacobs; Francisco Diez-Gonzalez
Journal: Appl Environ Microbiol Date: 2004-10 Impact factor: 4.792

10. Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.

Authors: Philip A Wescombe; Mathew Upton; Karen P Dierksen; Nancy L Ragland; Senthuran Sivabalan; Ruth E Wirawan; Megan A Inglis; Chris J Moore; Glenn V Walker; Chris N Chilcott; Howard F Jenkinson; John R Tagg
Journal: Appl Environ Microbiol Date: 2006-02 Impact factor: 4.792

12 in total

Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract.

1. Effects of Lactococcus lactis on composition of intestinal microbiota: role of nisin.

Review 2. Bacteriocins: developing innate immunity for food.

3. Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations.

4. An application in cheddar cheese manufacture for a strain of Lactococcus lactis producing a novel broad-spectrum bacteriocin, lacticin 3147.

5. Development of a lacticin 3147-enriched whey powder with inhibitory activity against foodborne pathogens.

6. Sites of organic acid production and pattern of digesta movement in the gastrointestinal tract of swine.

7. Effects of microcin 24-producing Escherichia coli on shedding and multiple-antimicrobial resistance of Salmonella enterica serotype typhimurium in pigs.

8. Campylobacter jejuni non-culturable coccoid cells.

9. Reduction of Escherichia coli O157:H7 populations in cattle by addition of colicin E7-producing E. coli to feed.

10. Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva.

Review 1. New horizons for host defense peptides and lantibiotics.

Review 2. Anti-infective properties of bacteriocins: an update.

Review 3. The manifold roles of microbial ribosomal peptide-based natural products in physiology and ecology.

Review 4. Therapeutic Application of Lantibiotics and Other Lanthipeptides: Old and New Findings.

Review 5. Antimicrobial activity of lactic acid bacteria in dairy products and gut: effect on pathogens.

6. Probiotics and gastrointestinal disease: successes, problems and future prospects.

Review 7. Recipe for Success: Suggestions and Recommendations for the Isolation and Characterisation of Bacteriocins.

Review 8. Cationic antimicrobial polymers and their assemblies.

9. Engineered E. coli Nissle 1917 for the reduction of vancomycin-resistant Enterococcus in the intestinal tract.

Review 10. Probiotic engineering strategies for the heterologous production of antimicrobial peptides.