| Literature DB >> 17766108 |
L B Hough1, W M P B Menge, A C van de Stolpe, J W Nalwalk, R Leurs, I J P de Esch.
Abstract
Furan-containing congeners of the histamine H(2) receptor antagonist ranitidine were synthesized and tested for improgan-like antinociceptive activity. The most potent ligand of the series, VUF5498, is the most potent improgan-like agent described to date (ED(50)=25 nmol, icv). This compound is approximately equal in potency with morphine. These non-imidazole, improgan-like pain relievers further define the structural requirements for analgesics of this class and are important tools for ongoing mechanism-based studies.Entities:
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Year: 2007 PMID： 17766108 PMCID： PMC2094356 DOI： 10.1016/j.bmcl.2007.07.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823