| Literature DB >> 17765966 |
Jose Roman-Gomez1, Antonio Jimenez-Velasco, Xabier Agirre, Juan A Castillejo, German Navarro, Edurne San Jose-Eneriz, Leire Garate, Lucia Cordeu, Francisco Cervantes, Felipe Prosper, Anabel Heiniger, Antonio Torres.
Abstract
Repetitive elements are heavily methylated in normal tissues, but hypomethylated in malignant tissues, driving the global genomic hypomethylation found in cancer. This hypomethylation results in chromosomal instability, a well-characterized feature of the advanced phases of chronic myeloid leukemia (CML). We investigated methylation changes of DNA repetitive elements (LINE1, Alu, Satellite-alpha and Satellite-2) during the progression of CML from chronic phase (CP) to blast crisis (BC). CP-CML samples were significantly more hypomethylated for all repetitive sequences compared with normal samples. Furthermore, a more profound level of hypomethylation was observed among BC samples compared with CP samples. Our data suggest that repetitive DNA hypomethylation are closely associated with CML progression.Entities:
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Year: 2007 PMID： 17765966 DOI： 10.1016/j.leukres.2007.07.021
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156