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Literature DB >> 17765282

Retinal degeneration in children: dark adapted visual threshold and arteriolar diameter.

Ronald M Hansen¹, Susan E Eklund, Ilan Y Benador, Julie A Mocko, James D Akula, Yao Liu, M Elena Martinez-Perez, Anne B Fulton.

Abstract

To assess the condition of the retina in children with retinal degeneration due to Bardet-Biedl syndrome (BBS, n=41), Leber congenital amaurosis (LCA, n=31), or Usher syndrome (USH, n=13), the dark adapted visual threshold (DAT) and arteriolar diameters were measured. Compared to controls, the initial DATs of nearly all (83/85) were significantly elevated, and in 26/62 with serial DATs, significant progressive elevation occurred. Arteriolar diameters were significantly attenuated and narrowed with age in BBS and USH, but not LCA. Higher DATs were associated with narrower arterioles. Such non-invasive procedures can document the natural history of these retinal diseases and have the potential to assess response to future treatment.

Entities: Disease Species

Mesh：

Year: 2007 PMID： 17765282 PMCID： PMC2476928 DOI： 10.1016/j.visres.2007.07.009

Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886

34 in total

1. The development of scotopic sensitivity.

Authors: A B Fulton; R M Hansen
Journal: Invest Ophthalmol Vis Sci Date: 2000-05 Impact factor: 4.799

2. Diagnosis of plus disease in retinopathy of prematurity using Retinal Image multiScale Analysis.

Authors: Rony Gelman; M Elena Martinez-Perez; Deborah K Vanderveen; Anne Moskowitz; Anne B Fulton
Journal: Invest Ophthalmol Vis Sci Date: 2005-12 Impact factor: 4.799

3. Segmentation of blood vessels from red-free and fluorescein retinal images.

Authors: M Elena Martinez-Perez; Alun D Hughes; Simon A Thom; Anil A Bharath; Kim H Parker
Journal: Med Image Anal Date: 2007-01-03 Impact factor: 8.545

Review 4. Usher syndrome: molecular links of pathogenesis, proteins and pathways.

Authors: Hannie Kremer; Erwin van Wijk; Tina Märker; Uwe Wolfrum; Ronald Roepman
Journal: Hum Mol Genet Date: 2006-10-15 Impact factor: 6.150

5. Effects of desferoxamine on retinal and visual function.

Authors: Ming Lu; Ronald M Hansen; Melody J Cunningham; Susan E Eklund; Anne B Fulton
Journal: Arch Ophthalmol Date: 2007-11

6. Evaluation of genotype-phenotype associations in leber congenital amaurosis.

Authors: Jennifer A Galvin; Gerald A Fishman; Edwin M Stone; Robert K Koenekoop
Journal: Retina Date: 2005 Oct-Nov Impact factor: 4.256

7. Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measures.

Authors: Alejandro J Roman; Sharon B Schwartz; Tomas S Aleman; Artur V Cideciyan; John D Chico; Elizabeth A M Windsor; Leigh M Gardner; Gui-Shuang Ying; Elaine E Smilko; Maureen G Maguire; Samuel G Jacobson
Journal: Exp Eye Res Date: 2005-02 Impact factor: 3.467

8. Distribution and associations of retinal vascular caliber with ethnicity, gender, and birth parameters in young children.

Authors: Ning Cheung; F M Amirul Islam; Seang M Saw; Anoop Shankar; Kristin de Haseth; Paul Mitchell; Tien Yin Wong
Journal: Invest Ophthalmol Vis Sci Date: 2007-03 Impact factor: 4.799

Review 9. Retinal remodeling during retinal degeneration.

Authors: Bryan W Jones; Robert E Marc
Journal: Exp Eye Res Date: 2005-08 Impact factor: 3.467

Review 10. Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.

Authors: Jan Reiners; Kerstin Nagel-Wolfrum; Karin Jürgens; Tina Märker; Uwe Wolfrum
Journal: Exp Eye Res Date: 2006-03-20 Impact factor: 3.467

8 in total

8. CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.

Authors: Tingting Li; Xuan Cai; Xiangning Wang; Xueyan Zhang; Hui Zhang; Biwei Xu; Shiwei Li; Jianyan Hu; Qiang Wu
Journal: J Diabetes Res Date: 2020-03-09 Impact factor: 4.011

8 in total

Retinal degeneration in children: dark adapted visual threshold and arteriolar diameter.

1. The development of scotopic sensitivity.

2. Diagnosis of plus disease in retinopathy of prematurity using Retinal Image multiScale Analysis.

3. Segmentation of blood vessels from red-free and fluorescein retinal images.

Review 4. Usher syndrome: molecular links of pathogenesis, proteins and pathways.

5. Effects of desferoxamine on retinal and visual function.

6. Evaluation of genotype-phenotype associations in leber congenital amaurosis.

7. Quantifying rod photoreceptor-mediated vision in retinal degenerations: dark-adapted thresholds as outcome measures.

8. Distribution and associations of retinal vascular caliber with ethnicity, gender, and birth parameters in young children.

Review 9. Retinal remodeling during retinal degeneration.

Review 10. Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.

1. Photoreceptor and postreceptor responses in congenital stationary night blindness.

Review 2. The neurovascular retina in retinopathy of prematurity.

3. Temporal summation in children with a history of retinopathy of prematurity.

4. Effect of retinopathy of prematurity on scotopic spatial summation.

Review 5. The neural retina in retinopathy of prematurity.

Review 6. Retinal degenerative and hypoxic ischemic disease.

7. Dark-adapted threshold and electroretinogram for diagnosis of Usher syndrome.

8. CCAAT/Enhancer-Binding Protein β Mediates Oxygen-Induced Retinal Neovascularization via Retinal Vascular Damage and Vascular Endothelial Growth Factor.