Literature DB >> 17764933

Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives.

Sajal Kumar Das1, Gautam Panda, Vinita Chaturvedi, Y S Manju, Anil K Gaikwad, Sudhir Sinha.   

Abstract

A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel-Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H(37)R(v) in vitro and showed MIC in the range of 3.12-25 microg/ml.

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Year:  2007        PMID： 17764933     DOI： 10.1016/j.bmcl.2007.07.089

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  N-Aroyl-3,5-bis(benzylidene)-4-piperidones: a novel class of antimycobacterial agents.

Authors:  Umashankar Das; Swagatika Das; Brian Bandy; James P Stables; Jonathan R Dimmock
Journal:  Bioorg Med Chem       Date:  2008-02-08       Impact factor: 3.641

2.  Light-induced metal-free transformations of unactivated pyridotriazoles.

Authors:  Ziyan Zhang; Dongari Yadagiri; Vladimir Gevorgyan
Journal:  Chem Sci       Date:  2019-07-25       Impact factor: 9.825

3.  Synthesis of novel naphthalene-heterocycle hybrids with potent antitumor, anti-inflammatory and antituberculosis activities.

Authors:  Mohamed Ahmed Abozeid; Aya Atef El-Sawi; Mohamed Abdelmoteleb; Hanem Awad; Marwa Mostafa Abdel-Aziz; Abdel-Rahman Hassan Abdel-Rahman; El-Sayed Ibrahim El-Desoky
Journal:  RSC Adv       Date:  2020-11-26       Impact factor: 4.036

4.  Organocatalytic enantioselective conjugate addition of 2-naphthols to ortho-hydroxyphenyl substituted para-quinone methides: access to unsymmetrical triarylmethanes.

Authors:  Yuyu Cheng; Zhiqiang Fang; Yanwen Jia; Zhongyue Lu; Wenjun Li; Pengfei Li
Journal:  RSC Adv       Date:  2019-08-05       Impact factor: 3.361

5.  NiXantphos: a deprotonatable ligand for room-temperature palladium-catalyzed cross-couplings of aryl chlorides.

Authors:  Jiadi Zhang; Ana Bellomo; Nisalak Trongsiriwat; Tiezheng Jia; Patrick J Carroll; Spencer D Dreher; Matthew T Tudge; Haolin Yin; Jerome R Robinson; Eric J Schelter; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2014-04-21       Impact factor: 15.419

6.  Nickel-Catalyzed Arylation of Heteroaryl-containing Diarylmethanes: Exceptional Reactivity of the Ni(NIXANTPHOS)-based Catalyst.

Authors:  Xinyu Cao; Sheng-Chun Sha; Minyan Li; Byeong-Seon Kim; Catherine Morgan; Rudan Huang; Xiaodong Yang; Patrick J Walsh
Journal:  Chem Sci       Date:  2015-10-26       Impact factor: 9.825
  6 in total

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