OBJECTIVES: To study the effect of duloxetine (Cymbalta), a selective serotonin and norepinephrine reuptake inhibitor, on pain symptoms in Parkinson Disease (PD). METHODS/PATIENTS: Twenty-three patients with PD with painful phenomena were treated with duloxetine for 6 weeks in an open-label design. Assessments were performed before and at treatment completion and consisted of a Visual Analogue Scale, the Brief Pain Inventory, Short-Form McGill Pain Questionnaire, Parkinson Disease Quality of Life Questionnaire-39-item version, and motor part of the Unified Parkinson Disease Rating Scale. Pain threshold was assessed by quantitative sensory tests. RESULTS: Thirteen of the 20 patients who completed the study reported varying degrees of pain relief. The mean Visual Analogue Scale, Brief Pain Inventory, and Short-Form McGill Pain Questionnaire scores decreased significantly. There was no change in pain threshold after treatment. CONCLUSIONS: Duloxetine seems to be effective for the treatment of central pain in PD.
OBJECTIVES: To study the effect of duloxetine (Cymbalta), a selective serotonin and norepinephrine reuptake inhibitor, on pain symptoms in Parkinson Disease (PD). METHODS/PATIENTS: Twenty-three patients with PD with painful phenomena were treated with duloxetine for 6 weeks in an open-label design. Assessments were performed before and at treatment completion and consisted of a Visual Analogue Scale, the Brief Pain Inventory, Short-Form McGill Pain Questionnaire, Parkinson Disease Quality of Life Questionnaire-39-item version, and motor part of the Unified Parkinson Disease Rating Scale. Pain threshold was assessed by quantitative sensory tests. RESULTS: Thirteen of the 20 patients who completed the study reported varying degrees of pain relief. The mean Visual Analogue Scale, Brief Pain Inventory, and Short-Form McGill Pain Questionnaire scores decreased significantly. There was no change in pain threshold after treatment. CONCLUSIONS:Duloxetine seems to be effective for the treatment of central pain in PD.
Authors: Santiago Perez-Lloret; Daniel Ciampi de Andrade; Kelly E Lyons; Carmen Rodríguez-Blázquez; Kallol Ray Chaudhuri; Guenther Deuschl; Girgio Cruccu; Cristina Sampaio; Christopher G Goetz; Anette Schrag; Pablo Martinez-Martin; Glenn Stebbins Journal: Mov Disord Clin Pract Date: 2016-06-24
Authors: Veit Mylius; Daniel Ciampi de Andrade; Rubens Gisbert Cury; Michael Teepker; Uwe Ehrt; Karla Maria Eggert; Serafin Beer; Jürg Kesselring; Maria Stamelou; Wolfgang H Oertel; Jens Carsten Möller; Jean-Pascal Lefaucheur Journal: Mov Disord Clin Pract Date: 2015-08-09