Veit Mylius1,2, Daniel Ciampi de Andrade3, Rubens Gisbert Cury3, Michael Teepker1, Uwe Ehrt4, Karla Maria Eggert1, Serafin Beer2, Jürg Kesselring2, Maria Stamelou1,5, Wolfgang H Oertel1, Jens Carsten Möller6, Jean-Pascal Lefaucheur7,8. 1. Department of Neurology Philipps University Marburg Germany. 2. Department of Neurology Center for Neurorehabilitation Valens Switzerland. 3. Pain Center Department of Neurology University of São Paulo São Paulo SP Brazil. 4. Psychiatric Clinic Fachklinikum Bernburg Bernburg Germany. 5. Movement Disorders Clinic Second Department of Neurology University of Athens Athens Greece. 6. Parkinson Center Center for Neurological Rehabilitation Zihlschlacht Switzerland. 7. Faculté de Médecine Université Paris Est Créteil Créteil France. 8. Service de Physiologie-Explorations Fonctionnelles Hôpital Henri Mondor Assistance Publique-Hôpitaux de Paris Créteil France.
Abstract
BACKGROUND: Pain is a significant burden for patients with Parkinson's disease (PD) with a high impact on quality of life. The present article aims at summarizing epidemiological, pathophysiological, clinical, and neurophysiological data regarding pain in PD. METHODS: In this domain, a procedure of systematic assessment is still lacking for the syndromic diagnosis and should take into account pain characteristics, effects of dopaminergic treatment, motor fluctuations, and non-PD-associated pain. FINDINGS: We propose an original questionnaire addressing an algorithm suitable for daily clinical practice. The questionnaire is based on a three-step approach addressing first the relationship between pain and PD (including temporal relationship with the course of the disease, association with motor fluctuations, and impact of antiparkinsonian treatment), before classifying pain into one of three main syndromes (i.e., musculoskeletal pain, psychomotor restlessness pain, and neuropathic pain). CONCLUSIONS: The proposed questionnaire allows the characteristics of each pain type to be determined according to its relationship with the disease and its treatment. The validation of the clinical use of this questionnaire will be the goal of a forthcoming work.
BACKGROUND: Pain is a significant burden for patients with Parkinson's disease (PD) with a high impact on quality of life. The present article aims at summarizing epidemiological, pathophysiological, clinical, and neurophysiological data regarding pain in PD. METHODS: In this domain, a procedure of systematic assessment is still lacking for the syndromic diagnosis and should take into account pain characteristics, effects of dopaminergic treatment, motor fluctuations, and non-PD-associated pain. FINDINGS: We propose an original questionnaire addressing an algorithm suitable for daily clinical practice. The questionnaire is based on a three-step approach addressing first the relationship between pain and PD (including temporal relationship with the course of the disease, association with motor fluctuations, and impact of antiparkinsonian treatment), before classifying pain into one of three main syndromes (i.e., musculoskeletal pain, psychomotor restlessness pain, and neuropathic pain). CONCLUSIONS: The proposed questionnaire allows the characteristics of each pain type to be determined according to its relationship with the disease and its treatment. The validation of the clinical use of this questionnaire will be the goal of a forthcoming work.
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Authors: Veit Mylius; Santiago Perez Lloret; Rubens G Cury; Manoel J Teixeira; Victor R Barbosa; Egberto R Barbosa; Larissa I Moreira; Clarice Listik; Ana M Fernandes; Diogo de Lacerda Veiga; Julio Barbour; Nathalie Hollenstein; Matthias Oechsner; Julia Walch; Florian Brugger; Stefan Hägele-Link; Serafin Beer; Alexandra Rizos; Kallol Ray Chaudhuri; Didier Bouhassira; Jean-Pascal Lefaucheur; Lars Timmermann; Roman Gonzenbach; Georg Kägi; Jens Carsten Möller; Daniel Ciampi de Andrade Journal: Pain Date: 2021-04-01 Impact factor: 7.926