Literature DB >> 1773824

Anti-sedative and anti-cataleptic properties of NCS-382, a gamma-hydroxybutyrate receptor antagonist.

C Schmidt1, S Gobaille, V Hechler, M Schmitt, J J Bourguignon, M Maitre.   

Abstract

NCS-382 possesses antagonistic properties at gamma-hydroxybutyrate receptor sites. Its effect on the sedative/cataleptic behaviour observed in rats after gamma-hydroxybutyrate administration was investigated. NCS-382 diminished, in a dose-dependent manner, the sedative and/or cataleptic effects of gamma-hydroxybutyrate, as revealed by a variety of sensorimotor tests. These results indicate that the well-known sedative/anaesthetic effects induced by gamma-hydroxybutyrate administration are provoked via stimulation of a specific class(es) of gamma-hydroxybutyrate receptors which exist in the rat brain and which could mediate a local stimulation of opiate synthesis and release.

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Year:  1991        PMID： 1773824     DOI： 10.1016/0014-2999(91)90896-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Extrasynaptic site of action for γ-hydroxybutyrate.

Authors:  S J Enna
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-31       Impact factor: 11.205

2.  Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons.

Authors:  Amy K Goodwin; Wolfgang Froestl; Elise M Weerts
Journal:  Psychopharmacology (Berl)       Date:  2005-03-01       Impact factor: 4.530

3.  Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice.

Authors:  M A King; J S Thinschmidt; D W Walker
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB).

Authors:  Nathan Absalom; Laura F Eghorn; Inge S Villumsen; Nasiara Karim; Tina Bay; Jesper V Olsen; Gitte M Knudsen; Hans Bräuner-Osborne; Bente Frølund; Rasmus P Clausen; Mary Chebib; Petrine Wellendorph
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-02       Impact factor: 11.205

5.  Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures.

Authors:  Nicolas Gervasi; Zohreh Monnier; Pierre Vincent; Daniele Paupardin-Tritsch; Stuart W Hughes; Vincenzo Crunelli; Nathalie Leresche
Journal:  J Neurosci       Date:  2003-12-10       Impact factor: 6.167

6.  Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.

Authors:  Changhong Li; Chengyang Liu; Itzhak Nissim; Jie Chen; Pan Chen; Nicolai Doliba; Tingting Zhang; Ilana Nissim; Yevgeny Daikhin; David Stokes; Marc Yudkoff; Michael J Bennett; Charles A Stanley; Franz M Matschinsky; Ali Naji
Journal:  J Biol Chem       Date:  2012-12-24       Impact factor: 5.157

Review 7.  A critical evaluation of the gamma-hydroxybutyrate (GHB) model of absence seizures.

Authors:  Marcello Venzi; Giuseppe Di Giovanni; Vincenzo Crunelli
Journal:  CNS Neurosci Ther       Date:  2014-11-18       Impact factor: 5.243

8.  Improvement in γ-hydroxybutyrate-induced contextual fear memory deficit by systemic administration of NCS-382.

Authors:  Keita Ishiwari; Ratna Sircar
Journal:  Neuroreport       Date:  2016-06-15       Impact factor: 1.837

9.  γ-Hydroxybutyric acid (GHB) is not an agonist of extrasynaptic GABAA receptors.

Authors:  William M Connelly; Adam C Errington; Vincenzo Crunelli
Journal:  PLoS One       Date:  2013-11-11       Impact factor: 3.240
  9 in total

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