Literature DB >> 17729039

Protein tyrosine phosphatase PTPN22 in human autoimmunity.

Torkel Vang1, Ana V Miletic, Nunzio Bottini, Tomas Mustelin.   

Abstract

The discovery that a single-nucleotide polymorphism (SNP) in lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, is associated with type 1 diabetes (T1D) has now been verified by numerous studies and has been expanded to rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus, Graves' disease, generalized vitiligo and other human autoimmune diseases. In this paper, we discuss the association of PTPN22 with autoimmunity, the biochemistry of the PTPN22-encoded phosphatase, and the molecular mechanism(s) by which the disease-predisposing allele contributes to the development of human disease.

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Year:  2007        PMID： 17729039     DOI： 10.1080/08916930701464897

Source DB:  PubMed          Journal:  Autoimmunity        ISSN： 0891-6934            Impact factor:   2.815


  59 in total

1.  The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies.

Authors:  M Maziarz; M Janer; J C Roach; W Hagopian; J P Palmer; K Deutsch; C B Sanjeevi; I Kockum; N Breslow; A Lernmark
Journal:  Genes Immun       Date:  2010-05-06       Impact factor: 2.676

Review 2.  The Contribution of PTPN22 to Rheumatic Disease.

Authors:  Tomas Mustelin; Nunzio Bottini; Stephanie M Stanford
Journal:  Arthritis Rheumatol       Date:  2019-03-02       Impact factor: 10.995

Review 3.  Genetic regulation of serum cytokines in systemic lupus erythematosus.

Authors:  Silvia N Kariuki; Timothy B Niewold
Journal:  Transl Res       Date:  2009-09-25       Impact factor: 7.012

Review 4.  Detecting shared pathogenesis from the shared genetics of immune-related diseases.

Authors:  Alexandra Zhernakova; Cleo C van Diemen; Cisca Wijmenga
Journal:  Nat Rev Genet       Date:  2009-01       Impact factor: 53.242

Review 5.  Relapse prediction in Graves´ disease: Towards mathematical modeling of clinical, immune and genetic markers.

Authors:  Christoph Langenstein; Diana Schork; Klaus Badenhoop; Eva Herrmann
Journal:  Rev Endocr Metab Disord       Date:  2016-12       Impact factor: 6.514

Review 6.  Extreme genetic risk for type 1A diabetes in the post-genome era.

Authors:  Erin E Baschal; George S Eisenbarth
Journal:  J Autoimmun       Date:  2008-05-01       Impact factor: 7.094

Review 7.  Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.

Authors:  Bernadette Biondi; George J Kahaly; R Paul Robertson
Journal:  Endocr Rev       Date:  2019-06-01       Impact factor: 19.871

8.  Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis.

Authors:  Chun-Huang Huang; James Cheng-Chung Wei; Chun-Chieh Chen; Chih-Shien Chuang; Chia-Hsuan Chou; Yu-Jie Lin; Ming-Fuu Wang; Ruey-Hong Wong
Journal:  Rheumatol Int       Date:  2013-11-09       Impact factor: 2.631

9.  PTPN22 gene functional polymorphism (rs2476601) in older adults with frailty syndrome.

Authors:  Rubén Rabaneda-Bueno; Norma Torres-Carrillo; José Alberto Ávila-Funes; Luis Miguel Gutiérrez-Robledo; Thalía Gabriela Pérez-Suárez; José Luis Acosta; Sara Torres-Castro; Ana Lilia Fletes-Rayas; Itzae Gutierrez-Hurtado; Elena Sandoval-Pinto; Rosa Cremades; Nora Magdalena Torres-Carrillo
Journal:  Mol Biol Rep       Date:  2021-02-21       Impact factor: 2.316

Review 10.  Mechanisms of autoimmune thyroid diseases: from genetics to epigenetics.

Authors:  Yaron Tomer
Journal:  Annu Rev Pathol       Date:  2014       Impact factor: 23.472
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