Literature DB >> 1772398

Genetic deficiency of complement component C8 in the rabbit: evidence of a translational defect in expression of the alpha-gamma subunit.

M Komatsu1, K Yamamoto, H Mikami, J M Sodetz.   

Abstract

We examined the molecular basis for rabbit C8 alpha-gamma deficiency (C8D) using human C8 cDNA probes. Sequential probing of normal rabbit poly(A)+RNA revealed messages of 2.1, 1.9, and 0.8 kb for alpha, beta, and gamma, respectively. Corresponding analysis of C8D rabbit poly(A)+RNA identified messages for alpha and gamma of the same size and amounts as normal rabbits. Thus, C8 alpha-gamma deficiency in the rabbit appears to be the result of a translational rather than a transcriptional defect.

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Year:  1991        PMID： 1772398     DOI： 10.1007/bf00590107

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  15 in total

1.  Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.

Authors:  A G Rao; O M Howard; S C Ng; A S Whitehead; H R Colten; J M Sodetz
Journal:  Biochemistry       Date:  1987-06-16       Impact factor: 3.162

2.  Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9.

Authors:  O M Howard; A G Rao; J M Sodetz
Journal:  Biochemistry       Date:  1987-06-16       Impact factor: 3.162

3.  The homology of complement factor C8 gamma chain and alpha-1-microglobulin.

Authors:  L T Hunt; A Elzanowski; W C Barker
Journal:  Biochem Biophys Res Commun       Date:  1987-11-30       Impact factor: 3.575

4.  Homology and structure-function correlations between alpha 1-acid glycoprotein and serum retinol-binding protein and its relatives.

Authors:  S Pervaiz; K Brew
Journal:  FASEB J       Date:  1987-09       Impact factor: 5.191

5.  The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes.

Authors:  S C Ng; A G Rao; O M Howard; J M Sodetz
Journal:  Biochemistry       Date:  1987-08-25       Impact factor: 3.162

6.  Biosynthesis of C8 by hepatocytes. Differential expression and intracellular association of the alpha-gamma- and beta-subunits.

Authors:  S C Ng; J M Sodetz
Journal:  J Immunol       Date:  1987-11-01       Impact factor: 5.422

7.  Two distinct abnormalities in patients with C8 alpha-gamma deficiency. Low level of C8 beta chain and presence of dysfunctional C8 alpha-gamma subunit.

Authors:  F Tedesco; L Roncelli; B H Petersen; V Agnello; J M Sodetz
Journal:  J Clin Invest       Date:  1990-09       Impact factor: 14.808

8.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

9.  Two types of dysfunctional eighth component of complement (C8) molecules in C8 deficiency in man. Reconstitution of normal C8 from the mixture of two abnormal C8 molecules.

Authors:  F Tedesco; P Densen; M A Villa; B H Petersen; G Sirchia
Journal:  J Clin Invest       Date:  1983-02       Impact factor: 14.808

10.  The membrane attack mechanism of complement: the three polypeptide chain structure of the eigth component (C8).

Authors:  W P Klob; H J Müller-Eberhard
Journal:  J Exp Med       Date:  1976-05-01       Impact factor: 14.307
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  1 in total

Review 1.  Animal models of inherited complement deficiency.

Authors:  S Linton
Journal:  Mol Biotechnol       Date:  2001-06       Impact factor: 2.695
  1 in total

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