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Literature DB >> 17720902

Significance thresholds for quantitative trait locus mapping under selective genotyping.

Ani Manichaikul¹, Abraham A Palmer, Saunak Sen, Karl W Broman.

Abstract

In the case of selective genotyping, the usual permutation test to establish statistical significance for quantitative trait locus (QTL) mapping can give inappropriate significance thresholds, especially when the phenotype distribution is skewed. A stratified permutation test should be used, with phenotypes shuffled separately within the genotyped and ungenotyped individuals.

Mesh：

Year: 2007 PMID： 17720902 PMCID： PMC2147971 DOI： 10.1534/genetics.107.080093

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

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