| Literature DB >> 17720561 |
E Bullitt1, S R Aylward, T Van Dyke, W Lin.
Abstract
Blood vessel morphology (vessel radius, branching pattern, and tortuosity) is altered by a multitude of diseases. Although murine models of human pathology are important to the investigation of many diseases, there are few publications that address quantitative measurements of murine vascular morphology. This report outlines methods of imaging mice in vivo using magnetic resonance angiograms obtained on a clinical 3T unit, of defining mouse vasculature from these images, and of quantifying measures of vessel shape. We provide examples of both healthy and diseased vasculature and illustrate how the approach can be used to assess pathology both visually and quantitatively. The method is amenable to the assessment of many diseases in both human beings and mice.Entities:
Mesh：
Year: 2007 PMID： 17720561 PMCID： PMC2000457 DOI： 10.1016/j.ymeth.2007.03.009
Source DB: PubMed Journal: Methods ISSN： 1046-2023 Impact factor: 3.608