Literature DB >> 17720495

Novel anti-tuberculosis agents from MCR libraries.

Alexander Dömling1, Sepp Achatz, Barbara Beck.   

Abstract

Structure-based design of libraries of multi-component reaction products yields novel potent anti-tuberculosis compounds. Synthesis and preliminary biological results are presented.

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Year:  2007        PMID： 17720495     DOI： 10.1016/j.bmcl.2007.04.066

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffold.

Authors:  Edward Avilés; Jacques Prudhomme; Karine G Le Roch; Scott G Franzblau; Kevin Chandrasena; Alejandro M S Mayer; Abimael D Rodríguez
Journal:  Bioorg Med Chem Lett       Date:  2015-09-15       Impact factor: 2.823

2.  Synthesis of some new triamide derivatives via Ugi five-component reaction in aqueous solution.

Authors:  Ali Asghar Mohammadi; Salman Taheri; Arman Amini; Reza Ahdenov
Journal:  Mol Divers       Date:  2018-06-27       Impact factor: 2.943

3.  Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.

Authors:  Brendan Frett; Marialuisa Moccia; Francesca Carlomagno; Massimo Santoro; Hong-yu Li
Journal:  Eur J Med Chem       Date:  2014-09-08       Impact factor: 6.514

4.  Applications of the Ugi reaction with ketones.

Authors:  Suvi T M Simila; Stephen F Martin
Journal:  Tetrahedron Lett       Date:  2008       Impact factor: 2.415

5.  Synthesis and Cytotoxic Analysis of Novel Myrtenyl Grafted Pseudo-Peptides Revealed Potential Candidates for Anticancer Therapy.

Authors:  Odette Concepción; Julio Belmar; Alexander F de la Torre; Francisco M Muñiz; Mariano W Pertino; Barbara Alarcón; Valeska Ormazabal; Estefania Nova-Lamperti; Felipe A Zúñiga; Claudio A Jiménez
Journal:  Molecules       Date:  2020-04-21       Impact factor: 4.411

6.  Novel Sulfamethoxazole Ureas and Oxalamide as Potential Antimycobacterial Agents.

Authors:  Martin Krátký; Jiřina Stolaříková; Jarmila Vinšová
Journal:  Molecules       Date:  2017-03-28       Impact factor: 4.411
  6 in total

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