Literature DB >> 17713777

Long-term impact of the women's health initiative on HRT.

Lynn Parente1, Catherine Uyehara, Wilma Larsen, Bradford Whitcomb, John Farley.   

Abstract

OBJECTIVE: To evaluate the long-term trends in the HRT following the results of the WHI, which were made public in July 2002. STUDY
DESIGN: An observational cohort study was performed from prescription data of estrogen containing products ordered from Tripler Army Medical Center between July 1999 and July 2005. We used automated pharmacy data to identify all estrogen products dispensed to active duty soldiers, dependent wives, and retirees during the study period. Differences in prescription rate were compared between groups using a Student's t-test.
RESULTS: A total of 71,592 prescriptions were written for HRT. Prescriptions decreased from 1,272/month at the start of the study to 493/month at the conclusion of the study. Prior to July 2002 OBGYNs were the first to decrease their prescribing rate of estrogen, and this decrease was greater than other specialties analyzed. The frequency of HRT prescriptions decreased after July 2002 while the percentage of patients who filled HRT prescriptions increased from 68 to 72%.
CONCLUSIONS: We have found a significant decrease in prescriptions after release of the WHI initiative results. With this decrease in prescribing rate of HRT we found that a greater percentage of women actually filled their prescriptions perhaps indicating greater certainty in their choice.

Entities:  

Mesh:

Year:  2007        PMID: 17713777     DOI: 10.1007/s00404-007-0442-1

Source DB:  PubMed          Journal:  Arch Gynecol Obstet        ISSN: 0932-0067            Impact factor:   2.344


  12 in total

1.  Long-term effect of the Women's Health Initiative study on antiosteoporosis medication prescribing.

Authors:  Euni Lee; Mary K Maneno; Anthony K Wutoh; Ilene H Zuckerman
Journal:  J Womens Health (Larchmt)       Date:  2010-05       Impact factor: 2.681

Review 2.  Update on estrogens and the skeleton.

Authors:  Sundeep Khosla
Journal:  J Clin Endocrinol Metab       Date:  2010-08       Impact factor: 5.958

3.  Mammographic breast density and tolerance for short-term postmenopausal hormone therapy suspension.

Authors:  Erin J Aiello Bowles; Melissa L Anderson; Susan D Reed; Katherine M Newton; E Dawn Fitzgibbons; Deborah Seger; Diana S M Buist
Journal:  J Womens Health (Larchmt)       Date:  2010-08       Impact factor: 2.681

Review 4.  The molecular mechanisms underlying the pharmacological actions of estrogens, SERMs and oxysterols: implications for the treatment and prevention of osteoporosis.

Authors:  Erik R Nelson; Suzanne E Wardell; Donald P McDonnell
Journal:  Bone       Date:  2012-11-17       Impact factor: 4.398

5.  Female hormonal and reproductive factors and head and neck squamous cell carcinoma risk.

Authors:  Scott M Langevin; Jennifer R Grandis; Emanuela Taioli
Journal:  Cancer Lett       Date:  2011-07-12       Impact factor: 8.679

6.  Cellular senescence in bone.

Authors:  Joshua N Farr; Sundeep Khosla
Journal:  Bone       Date:  2019-01-16       Impact factor: 4.398

7.  Hip fracture in postmenopausal women after cessation of hormone therapy: results from a prospective study in a large health management organization.

Authors:  Roksana Karim; Richard M Dell; Denise F Greene; Wendy J Mack; J Christopher Gallagher; Howard N Hodis
Journal:  Menopause       Date:  2011-11       Impact factor: 2.953

Review 8.  Premature menopause or early menopause and risk of ischemic stroke.

Authors:  Walter A Rocca; Brandon R Grossardt; Virginia M Miller; Lynne T Shuster; Robert D Brown
Journal:  Menopause       Date:  2012-03       Impact factor: 2.953

9.  Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans.

Authors:  Joshua N Farr; Jennifer L Rowsey; Brittany A Eckhardt; Brianne S Thicke; Daniel G Fraser; Tamar Tchkonia; James L Kirkland; David G Monroe; Sundeep Khosla
Journal:  J Bone Miner Res       Date:  2019-06-21       Impact factor: 6.741

Review 10.  Why do stress and urge incontinence co-occur much more often than expected?

Authors:  Vatche A Minassian; Walter F Stewart; Annemarie G Hirsch
Journal:  Int Urogynecol J Pelvic Floor Dysfunct       Date:  2008-06-05
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