Literature DB >> 17712044

The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans.

Stephan Menzel1, Jie Jiang, Nicholas Silver, Joy Gallagher, Juliette Cunningham, Gabriela Surdulescu, Mark Lathrop, Martin Farrall, Tim D Spector, Swee Lay Thein.   

Abstract

Common sequence variants situated between the HBS1L and MYB genes on chromosome 6q23.3 (HMIP) influence the proportion of F cells (erythrocytes that carry measurable amounts of fetal hemoglobin). Since the physiological processes underlying the F-cell variability are thought to be linked to kinetics of erythrocyte maturation and differentiation, we have investigated the influence of the HMIP locus on other hematologic parameters. Here we show a significant impact of HMIP variability on several types of peripheral blood cells: erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content in healthy individuals of European ancestry. These results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans.

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Year:  2007        PMID： 17712044     DOI： 10.1182/blood-2007-05-093419

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  37 in total

1.  Beta-thalassemia: from genotype to phenotype.

Authors:  Fabrice Danjou; Franco Anni; Renzo Galanello
Journal:  Haematologica       Date:  2011-11       Impact factor: 9.941

2.  Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.

Authors:  Daniel F Gudbjartsson; Unnur S Bjornsdottir; Eva Halapi; Anna Helgadottir; Patrick Sulem; Gudrun M Jonsdottir; Gudmar Thorleifsson; Hafdis Helgadottir; Valgerdur Steinthorsdottir; Hreinn Stefansson; Carolyn Williams; Jennie Hui; John Beilby; Nicole M Warrington; Alan James; Lyle J Palmer; Gerard H Koppelman; Andrea Heinzmann; Marcus Krueger; H Marike Boezen; Amanda Wheatley; Janine Altmuller; Hyoung Doo Shin; Soo-Taek Uh; Hyun Sub Cheong; Brynja Jonsdottir; David Gislason; Choon-Sik Park; Linda M Rasmussen; Celeste Porsbjerg; Jakob W Hansen; Vibeke Backer; Thomas Werge; Christer Janson; Ulla-Britt Jönsson; Maggie C Y Ng; Juliana Chan; Wing Yee So; Ronald Ma; Svati H Shah; Christopher B Granger; Arshed A Quyyumi; Allan I Levey; Viola Vaccarino; Muredach P Reilly; Daniel J Rader; Michael J A Williams; Andre M van Rij; Gregory T Jones; Elisabetta Trabetti; Giovanni Malerba; Pier Franco Pignatti; Attilio Boner; Lydia Pescollderungg; Domenico Girelli; Oliviero Olivieri; Nicola Martinelli; Bjorn R Ludviksson; Dora Ludviksdottir; Gudmundur I Eyjolfsson; David Arnar; Gudmundur Thorgeirsson; Klaus Deichmann; Philip J Thompson; Matthias Wjst; Ian P Hall; Dirkje S Postma; Thorarinn Gislason; Jeffrey Gulcher; Augustine Kong; Ingileif Jonsdottir; Unnur Thorsteinsdottir; Kari Stefansson
Journal:  Nat Genet       Date:  2009-02-08       Impact factor: 38.330

Review 3.  Transcriptional mechanisms underlying hemoglobin synthesis.

Authors:  Koichi R Katsumura; Andrew W DeVilbiss; Nathaniel J Pope; Kirby D Johnson; Emery H Bresnick
Journal:  Cold Spring Harb Perspect Med       Date:  2013-09-01       Impact factor: 6.915

4.  A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.

Authors:  Khader Shameer; Joshua C Denny; Keyue Ding; Hayan Jouni; David R Crosslin; Mariza de Andrade; Christopher G Chute; Peggy Peissig; Jennifer A Pacheco; Rongling Li; Lisa Bastarache; Abel N Kho; Marylyn D Ritchie; Daniel R Masys; Rex L Chisholm; Eric B Larson; Catherine A McCarty; Dan M Roden; Gail P Jarvik; Iftikhar J Kullo
Journal:  Hum Genet       Date:  2013-09-12       Impact factor: 4.132

5.  Dissection of the Major Hematopoietic Quantitative Trait Locus in Chromosome 6q23.3 Identifies miR-3662 as a Player in Hematopoiesis and Acute Myeloid Leukemia.

Authors:  Sophia E Maharry; Christopher J Walker; Sandya Liyanarachchi; Sujay Mehta; Mitra Patel; Maryam A Bainazar; Xiaomeng Huang; Malori A Lankenau; Kevin W Hoag; Parvathi Ranganathan; Ramiro Garzon; James S Blachly; Denis C Guttridge; Clara D Bloomfield; Albert de la Chapelle; Ann-Kathrin Eisfeld
Journal:  Cancer Discov       Date:  2016-06-27       Impact factor: 39.397

6.  Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.

Authors:  Nadia Solovieff; Jacqueline N Milton; Stephen W Hartley; Richard Sherva; Paola Sebastiani; Daniel A Dworkis; Elizabeth S Klings; Lindsay A Farrer; Melanie E Garrett; Allison Ashley-Koch; Marilyn J Telen; Supan Fucharoen; Shau Yin Ha; Chi-Kong Li; David H K Chui; Clinton T Baldwin; Martin H Steinberg
Journal:  Blood       Date:  2009-12-16       Impact factor: 22.113

7.  Dom34 rescues ribosomes in 3' untranslated regions.

Authors:  Nicholas R Guydosh; Rachel Green
Journal:  Cell       Date:  2014-02-27       Impact factor: 41.582

Review 8.  Hydroxyurea for reducing blood transfusion in non-transfusion dependent beta thalassaemias.

Authors:  Wai Cheng Foong; Jacqueline J Ho; C Khai Loh; Vip Viprakasit
Journal:  Cochrane Database Syst Rev       Date:  2016-10-18

9.  DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

Authors:  Guillaume Lettre; Vijay G Sankaran; Marcos André C Bezerra; Aderson S Araújo; Manuela Uda; Serena Sanna; Antonio Cao; David Schlessinger; Fernando F Costa; Joel N Hirschhorn; Stuart H Orkin
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-30       Impact factor: 11.205

10.  Disruption of the Hbs1l-Myb locus causes hereditary persistence of fetal hemoglobin in a mouse model.

Authors:  Mikiko Suzuki; Hiromi Yamazaki; Harumi Y Mukai; Hozumi Motohashi; Lihong Shi; Osamu Tanabe; James Douglas Engel; Masayuki Yamamoto
Journal:  Mol Cell Biol       Date:  2013-02-19       Impact factor: 4.272
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