INTRODUCTION: Hepatic hemangioendothelioma (HEH) is a vascular neoplasm with intermediate malignant potential. Outcomes after liver transplantation have only been reported as small, single-institution experiences. The purpose of this study was to evaluate patient and allograft survivals after liver transplantation in a large, multi-institutional cohort of patients with HEH. METHODS: Using the United Network for Organ Sharing (UNOS) database, we identified 110 patients with a diagnosis of HEH who underwent 126 transplants between 1987 and 2005. Patient and allograft survivals were calculated using Kaplan-Meier survival curves. Log rank tests were used to determine the influence of study variables on outcomes. RESULTS: Of the 110 transplanted patients, 75 patients (68%) were female, 80 patients (73%) were Caucasian, and the median age was 36 years old (23%<4 y.o., 71%>18 y.o.). The 30-day posttransplant mortality rate was 2.4%. At a median patient follow-up interval of 24 months, 1- and 5-year patient and allograft survivals were 80% and 64%, and 70% and 55%, respectively. Pretransplant medical status, but not age, was found to statistically correlate with patient survival. CONCLUSION: These data indicate that survivals after transplantation for HEH are favorable. Given the propensity for recurrence after resection, these data support consideration of liver transplantation for all patients with significant intrahepatic tumor burden.
INTRODUCTION:Hepatic hemangioendothelioma (HEH) is a vascular neoplasm with intermediate malignant potential. Outcomes after liver transplantation have only been reported as small, single-institution experiences. The purpose of this study was to evaluate patient and allograft survivals after liver transplantation in a large, multi-institutional cohort of patients with HEH. METHODS: Using the United Network for Organ Sharing (UNOS) database, we identified 110 patients with a diagnosis of HEH who underwent 126 transplants between 1987 and 2005. Patient and allograft survivals were calculated using Kaplan-Meier survival curves. Log rank tests were used to determine the influence of study variables on outcomes. RESULTS: Of the 110 transplanted patients, 75 patients (68%) were female, 80 patients (73%) were Caucasian, and the median age was 36 years old (23%<4 y.o., 71%>18 y.o.). The 30-day posttransplant mortality rate was 2.4%. At a median patient follow-up interval of 24 months, 1- and 5-year patient and allograft survivals were 80% and 64%, and 70% and 55%, respectively. Pretransplant medical status, but not age, was found to statistically correlate with patient survival. CONCLUSION: These data indicate that survivals after transplantation for HEH are favorable. Given the propensity for recurrence after resection, these data support consideration of liver transplantation for all patients with significant intrahepatic tumor burden.
Authors: M d'Annibale; P Piovanello; P Carlini; F Del Nonno; F Sciarretta; M Rossi; P Berloco; M Iappelli; M T Lonardo; R Perrone; R Donnorso Journal: Transplant Proc Date: 2002-06 Impact factor: 1.066
Authors: Arianeb Mehrabi; Arash Kashfi; Hamidreza Fonouni; Peter Schemmer; Bruno M Schmied; Peter Hallscheidt; Peter Schirmacher; Jurgen Weitz; Helmut Friess; Markus W Buchler; Jan Schmidt Journal: Cancer Date: 2006-11-01 Impact factor: 6.860
Authors: M Ben-Haim; S Roayaie; M Q Ye; S N Thung; S Emre; T A Fishbein; P M Sheiner; C M Miller; M E Schwartz Journal: Liver Transpl Surg Date: 1999-11
Authors: Arianeb Mehrabi; Arash Kashfi; Peter Schemmer; Peter Sauer; Jens Encke; Hamidreza Fonouni; Helmut Friess; Jürgen Weitz; Jan Schmidt; Markus W Büchler; Thomas W Kraus Journal: Transplantation Date: 2005-09-27 Impact factor: 4.939
Authors: I R Marino; S Todo; A G Tzakis; G Klintmalm; M Kelleher; S Iwatsuki; T E Starzl; C O Esquivel Journal: Cancer Date: 1988-11-15 Impact factor: 6.860
Authors: Yueyi I Liu; Saghi S Brown; Arvand Elihu; C Andrew Bonham; Waldo Concepcion; Teri A Longacre; Aya Kamaya Journal: Dig Dis Sci Date: 2010-10-30 Impact factor: 3.199
Authors: Travis E Grotz; David Nagorney; John Donohue; Florencia Que; Michael Kendrick; Michael Farnell; Scott Harmsen; David Mulligan; Justin Nguyen; Charles Rosen; Kaye M Reid-Lombardo Journal: HPB (Oxford) Date: 2010-09-02 Impact factor: 3.647
Authors: Piotr Remiszewski; Ewa Szczerba; Piotr Kalinowski; Beata Gierej; Krzysztof Dudek; Mariusz Grodzicki; Marcin Kotulski; Rafał Paluszkiewicz; Waldemar Patkowski; Krzysztof Zieniewicz; Marek Krawczyk Journal: World J Gastroenterol Date: 2014-08-28 Impact factor: 5.742
Authors: Carmine G Nudo; Eric M Yoshida; Vincent G Bain; Denis Marleau; Phil Wong; Paul J Marotta; Eberhard Renner; Kymberly D Watt; Marc Deschênes Journal: Can J Gastroenterol Date: 2008-10 Impact factor: 3.522
Authors: Edward B Breitschwerdt; Ricardo G Maggi; Mrudula Varanat; Keith E Linder; Guy Weinberg Journal: J Clin Microbiol Date: 2009-04-15 Impact factor: 5.948