Literature DB >> 17707921

Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice.

Daniela Babovic1, Colm M O'Tuathaigh, Gerard J O'Sullivan, Jeremiah J Clifford, Orna Tighe, David T Croke, Maria Karayiorgou, Joseph A Gogos, David Cotter, John L Waddington.   

Abstract

Catechol-O-methyltransferase (COMT) inactivates dopamine in prefrontal cortex and is associated clinically with a schizophrenia endophenotype. Using an ethologically based approach, the phenotype of mice with heterozygous COMT deletion was characterised by decreased rearing with increased sifting and chewing. Heterozygous COMT deletion is associated with a distinctive phenotype. This differs from that which we have reported previously for heterozygous deletion of the schizophrenia risk gene neuregulin-1.

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Year:  2007        PMID： 17707921     DOI： 10.1016/j.bbr.2007.07.006

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  10 in total

Review 1.  Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders.

Authors:  Michael R Hunsaker
Journal:  Prog Neurobiol       Date:  2012-01-13       Impact factor: 11.685

Review 2.  Animal models of gene-environment interaction in schizophrenia: A dimensional perspective.

Authors:  Yavuz Ayhan; Ross McFarland; Mikhail V Pletnikov
Journal:  Prog Neurobiol       Date:  2015-10-25       Impact factor: 11.685

3.  Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways.

Authors:  Aine T Behan; Magdalena Hryniewiecka; Colm M P O'Tuathaigh; Anthony Kinsella; Mary Cannon; Maria Karayiorgou; Joseph A Gogos; John L Waddington; David R Cotter
Journal:  Neuropsychopharmacology       Date:  2012-03-21       Impact factor: 7.853

4.  Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.

Authors:  Colm M P O'Tuathaigh; Magdalena Hryniewiecka; Aine Behan; Orna Tighe; Catherine Coughlan; Lieve Desbonnet; Mary Cannon; Maria Karayiorgou; Joseph A Gogos; David R Cotter; John L Waddington
Journal:  Neuropsychopharmacology       Date:  2010-07-14       Impact factor: 7.853

5.  Of mice and men: bridging the translational disconnect in CNS drug discovery.

Authors:  Hugo Geerts
Journal:  CNS Drugs       Date:  2009-11       Impact factor: 5.749

Review 6.  Criteria for validating mouse models of psychiatric diseases.

Authors:  Kathryn K Chadman; Mu Yang; Jacqueline N Crawley
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2009-01-05       Impact factor: 3.568

7.  Enhanced latent inhibition in dopamine receptor-deficient mice is sex-specific for the D1 but not D2 receptor subtype: implications for antipsychotic drug action.

Authors:  Cecilie Bay-Richter; Colm M P O'Tuathaigh; Gerard O'Sullivan; David M Heery; John L Waddington; Paula M Moran
Journal:  Int J Neuropsychopharmacol       Date:  2008-11-17       Impact factor: 5.176

8.  A B2 SINE insertion in the Comt1 gene (Comt1(B2i)) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains.

Authors:  R L Kember; C Fernandes; E M Tunbridge; L Liu; J L Payá-Cano; M J Parsons; L C Schalkwyk
Journal:  Genes Brain Behav       Date:  2010-11       Impact factor: 3.449

9.  Pathways to age of onset of heroin use: a structural model approach exploring the relationship of the COMT gene, impulsivity and childhood trauma.

Authors:  Ting Li; Jiang Du; Shunying Yu; Haifeng Jiang; Yingmei Fu; Dongxiang Wang; Haiming Sun; Hanhui Chen; Min Zhao
Journal:  PLoS One       Date:  2012-11-14       Impact factor: 3.240

Review 10.  Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.

Authors:  James N Samsom; Albert H C Wong
Journal:  Front Psychiatry       Date:  2015-02-18       Impact factor: 4.157
  10 in total

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