| Literature DB >> 17707552 |
Eloy Rodríguez-Rodríguez1, Jon Infante, Javier Llorca, Ignacio Mateo, Coro Sánchez-Quintana, Inés García-Gorostiaga, Pascual Sánchez-Juan, José Berciano, Onofre Combarros.
Abstract
An association between memory performance in healthy young, middle aged an elderly subjects and variability in the KIBRA gene (rs17070145) has been recently described. We analyzed this polymorphism in 391 sporadic Alzheimer's disease (AD) patients and 428 cognitively normal control subjects. The current study reveals that KIBRA (rs17070145) T allele (CT and TT genotypes) is associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) AD.Entities:
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Year: 2007 PMID： 17707552 DOI： 10.1016/j.neurobiolaging.2007.07.003
Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673