Literature DB >> 17706836

Regulation of TLR expression, a new perspective for the role of VIP in immunity.

R P Gomariz1, A Arranz, Y Juarranz, I Gutierrez-Cañas, M Garcia-Gomez, J Leceta, C Martínez.   

Abstract

The contribution of VIP immune functions to the regulation of homeostasis and health is well known. Modulation of immune responses through new therapeutics is one of the main goals of physicians and scientists seeking to control inflammatory/autoimmune diseases in humans. Initial therapeutic strategies targeted adaptive immune responses; discovery of Toll-like receptors (TLR) has widened the horizon to include targeting the innate immune system. In this review we have summarized recent information about VIP modulation of TLR function, and we suggest that VIP represents a new therapeutic option in the management of several pathologies.

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Year:  2007        PMID： 17706836     DOI： 10.1016/j.peptides.2007.07.005

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  16 in total

1.  Vasoactive intestinal peptide downregulates proinflammatory TLRs while upregulating anti-inflammatory TLRs in the infected cornea.

Authors:  Xiaoyu Jiang; Sharon A McClellan; Ronald P Barrett; Yunfan Zhang; Linda D Hazlett
Journal:  J Immunol       Date:  2012-06-01       Impact factor: 5.422

Review 2.  The role of Toll-like receptors in renal diseases.

Authors:  Anna Gluba; Maciej Banach; Simon Hannam; Dimitri P Mikhailidis; Agata Sakowicz; Jacek Rysz
Journal:  Nat Rev Nephrol       Date:  2010-02-23       Impact factor: 28.314

3.  Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles.

Authors:  Sandra Reichstetter; Gerardo M Castillo; Israel Rubinstein; Akiko Nishimoto-Ashfield; Manshun Lai; Cynthia C Jones; Aryamitra A Banerjee; Aryamitra Banjeree; Alex Lyubimov; Duane C Bloedow; Alexei Bogdanov; Elijah M Bolotin
Journal:  Pharm Res       Date:  2012-12-07       Impact factor: 4.200

4.  Absence of vasoactive intestinal peptide expression in hematopoietic cells enhances Th1 polarization and antiviral immunity in mice.

Authors:  Jian-Ming Li; Lauren Southerland; Mohammad S Hossain; Cynthia R Giver; Ying Wang; Kasia Darlak; Wayne Harris; James Waschek; Edmund K Waller
Journal:  J Immunol       Date:  2011-06-15       Impact factor: 5.422

5.  Focal, but not global, cerebral ischaemia causes loss of myenteric neurons and upregulation of vasoactive intestinal peptide in mouse ileum.

Authors:  Xiaowen Cheng; Martina Svensson; Yiyi Yang; Tomas Deierborg; Eva Ekblad; Ulrikke Voss
Journal:  Int J Exp Pathol       Date:  2018-03-25       Impact factor: 1.925

6.  Vasoactive intestinal peptide is required in the maintenance of immune regulatory competency of immune regulatory monocytes.

Authors:  L Guan; D Yu; G-H Wu; H-J Ning; S-D He; S-S Li; T-Y Hu; G Yang; Z-Q Liu; H-Q Yu; X-Z Sun; Z-G Liu; P-C Yang
Journal:  Clin Exp Immunol       Date:  2019-01-30       Impact factor: 4.330

7.  The expression of vasoactive intestinal peptide receptor 1 is negatively modulated by microRNA 525-5p.

Authors:  Elisa Cocco; Fabiana Paladini; Giuseppe Macino; Valerio Fulci; Maria Teresa Fiorillo; Rosa Sorrentino
Journal:  PLoS One       Date:  2010-08-10       Impact factor: 3.240

8.  Monocytes from Sjögren's syndrome patients display increased vasoactive intestinal peptide receptor 2 expression and impaired apoptotic cell phagocytosis.

Authors:  V Hauk; L Fraccaroli; E Grasso; A Eimon; R Ramhorst; O Hubscher; C Pérez Leirós
Journal:  Clin Exp Immunol       Date:  2014-09       Impact factor: 4.330

9.  Vasoactive intestinal peptide inhibits TNF-alpha-induced apoptotic events in acinar cells from nonobese diabetic mice submandibular glands.

Authors:  Mario Calafat; Luciana Larocca; Valeria Roca; Vanesa Hauk; Nicolás Pregi; Alcira Nesse; Claudia Pérez Leirós
Journal:  Arthritis Res Ther       Date:  2009-04-08       Impact factor: 5.156

10.  Mechanism of Immunoregulatory Properties of Vasoactive Intestinal Peptide in the K/BxN Mice Model of Autoimmune Arthritis.

Authors:  Javier Leceta; Marina I Garin; Carmen Conde
Journal:  Front Immunol       Date:  2021-07-16       Impact factor: 7.561
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