Literature DB >> 17706299

JBP2, a SWI2/SNF2-like protein, regulates de novo telomeric DNA glycosylation in bloodstream form Trypanosoma brucei.

Rudo Kieft1, Verena Brand, Dilrukshi K Ekanayake, Kate Sweeney, Courtney DiPaolo, William S Reznikoff, Robert Sabatini.   

Abstract

Synthesis of the modified thymine base, beta-d-glucosyl-hydroxymethyluracil or J, within telomeric DNA of Trypanosoma brucei correlates with the bloodstream form specific epigenetic silencing of telomeric variant surface glycoprotein genes involved in antigenic variation. In order to analyze the function of base J in the regulation of antigenic variation, we are characterizing the regulatory mechanism of J biosynthesis. We have recently proposed a model in which chromatin remodeling by a SWI2/SNF2-like protein (JBP2) regulates the developmental and de novo site-specific localization of J synthesis within bloodstream form trypanosome DNA. Consistent with this model, we now show that JBP2 (-/-) bloodstream form trypanosomes contain five-fold less base J and are unable to stimulate de novo J synthesis in newly generated telomeric arrays.

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Year:  2007        PMID： 17706299      PMCID： PMC4735730          DOI： 10.1016/j.molbiopara.2007.06.010

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  14 in total

1.  beta-D-glucosyl-hydroxymethyluracil is a conserved DNA modification in kinetoplastid protozoans and is abundant in their telomeres.

Authors:  F van Leeuwen; M C Taylor; A Mondragon; H Moreau; W Gibson; R Kieft; P Borst
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

2.  Activation of trypanosome surface glycoprotein genes involves a duplication-transposition leading to an altered 3' end.

Authors:  A Bernards; L H Van der Ploeg; A C Frasch; P Borst; J C Boothroyd; S Coleman; G A Cross
Journal:  Cell       Date:  1981-12       Impact factor: 41.582

3.  beta-D-glucosyl-hydroxymethyluracil: a novel modified base present in the DNA of the parasitic protozoan T. brucei.

Authors:  J H Gommers-Ampt; F Van Leeuwen; A L de Beer; J F Vliegenthart; M Dizdaroglu; J A Kowalak; P F Crain; P Borst
Journal:  Cell       Date:  1993-12-17       Impact factor: 41.582

4.  The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans.

Authors:  M Cross; R Kieft; R Sabatini; M Wilm; M de Kort; G A van der Marel; J H van Boom; F van Leeuwen; P Borst
Journal:  EMBO J       Date:  1999-11-15       Impact factor: 11.598

Review 5.  beta-D-glucosyl-hydroxymethyluracil, a novel base in African trypanosomes and other Kinetoplastida.

Authors:  P Borst; F van Leeuwen
Journal:  Mol Biochem Parasitol       Date:  1997-12-01       Impact factor: 1.759

6.  Repression of polymerase I-mediated gene expression at Trypanosoma brucei telomeres.

Authors:  Lucy Glover; David Horn
Journal:  EMBO Rep       Date:  2006-01       Impact factor: 8.807

7.  Recognition of base J in duplex DNA by J-binding protein.

Authors:  Robert Sabatini; Nico Meeuwenoord; Jacques H van Boom; Piet Borst
Journal:  J Biol Chem       Date:  2001-11-07       Impact factor: 5.157

8.  Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis.

Authors:  Sebastian Ulbert; Mike Cross; Robert J Boorstein; George W Teebor; Piet Borst
Journal:  Nucleic Acids Res       Date:  2002-09-15       Impact factor: 16.971

9.  J-binding protein increases the level and retention of the unusual base J in trypanosome DNA.

Authors:  Mike Cross; Rudo Kieft; Robert Sabatini; Anita Dirks-Mulder; Inês Chaves; Piet Borst
Journal:  Mol Microbiol       Date:  2002-10       Impact factor: 3.501

10.  Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei.

Authors:  F van Leeuwen; R Kieft; M Cross; P Borst
Journal:  Mol Cell Biol       Date:  1998-10       Impact factor: 4.272
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  14 in total

Review 1.  Epigenetic regulation in African trypanosomes: a new kid on the block.

Authors:  Luisa M Figueiredo; George A M Cross; Christian J Janzen
Journal:  Nat Rev Microbiol       Date:  2009-07       Impact factor: 60.633

Review 2.  Chromatin modifications, epigenetics, and how protozoan parasites regulate their lives.

Authors:  Matthew M Croken; Sheila C Nardelli; Kami Kim
Journal:  Trends Parasitol       Date:  2012-04-03

3.  Epigenetic regulation of transcription and virulence in Trypanosoma cruzi by O-linked thymine glucosylation of DNA.

Authors:  Dilrukshi K Ekanayake; Todd Minning; Brent Weatherly; Kapila Gunasekera; Daniel Nilsson; Rick Tarleton; Torsten Ochsenreiter; Robert Sabatini
Journal:  Mol Cell Biol       Date:  2011-02-14       Impact factor: 4.272

4.  JBP1 and JBP2 proteins are Fe2+/2-oxoglutarate-dependent dioxygenases regulating hydroxylation of thymidine residues in trypanosome DNA.

Authors:  Laura J Cliffe; Gwen Hirsch; Jin Wang; Dilrukshi Ekanayake; Whitney Bullard; Muhan Hu; Yinsheng Wang; Robert Sabatini
Journal:  J Biol Chem       Date:  2012-04-18       Impact factor: 5.157

5.  Fe(II)/alpha-ketoglutarate hydroxylases involved in nucleobase, nucleoside, nucleotide, and chromatin metabolism.

Authors:  Jana M Simmons; Tina A Müller; Robert P Hausinger
Journal:  Dalton Trans       Date:  2008-06-27       Impact factor: 4.390

6.  Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei.

Authors:  Laura J Cliffe; T Nicolai Siegel; Marion Marshall; George A M Cross; Robert Sabatini
Journal:  Nucleic Acids Res       Date:  2010-03-09       Impact factor: 16.971

7.  Identification of the glucosyltransferase that converts hydroxymethyluracil to base J in the trypanosomatid genome.

Authors:  Whitney Bullard; Jessica Lopes da Rosa-Spiegler; Shuo Liu; Yinsheng Wang; Robert Sabatini
Journal:  J Biol Chem       Date:  2014-06-02       Impact factor: 5.157

8.  Quantitative mass spectrometry-based analysis of β-D-glucosyl-5-hydroxymethyluracil in genomic DNA of Trypanosoma brucei.

Authors:  Shuo Liu; Debin Ji; Laura Cliffe; Robert Sabatini; Yinsheng Wang
Journal:  J Am Soc Mass Spectrom       Date:  2014-07-31       Impact factor: 3.109

9.  The structural basis for recognition of base J containing DNA by a novel DNA binding domain in JBP1.

Authors:  Tatjana Heidebrecht; Evangelos Christodoulou; Michael J Chalmers; Sabrina Jan; Bas Ter Riet; Rajesh K Grover; Robbie P Joosten; Dene Littler; Henri van Luenen; Patrick R Griffin; Paul Wentworth; Piet Borst; Anastassis Perrakis
Journal:  Nucleic Acids Res       Date:  2011-03-16       Impact factor: 16.971

10.  JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes.

Authors:  Laura J Cliffe; Rudo Kieft; Timothy Southern; Shanda R Birkeland; Marion Marshall; Kate Sweeney; Robert Sabatini
Journal:  Nucleic Acids Res       Date:  2009-01-09       Impact factor: 16.971
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