| Literature DB >> 17706201 |
Nicolas Quoix1, Rui Cheng-Xue, Yves Guiot, Pedro L Herrera, Jean-Claude Henquin, Patrick Gilon.
Abstract
The control of glucagon secretion by pancreatic alpha-cells is poorly understood, largely because of the difficulty to recognize living alpha-cells. We describe a new mouse model, referred to as GluCre-ROSA26EYFP (or GYY), allowing easy alpha-cell identification because of specific expression of EYFP. GYY mice displayed normal glycemic control during a fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated islets was normally inhibited by glucose and stimulated by adrenaline. [Ca(2+)](c) responses to arginine, adrenaline, diazoxide and tolbutamide, were similar in GYY and control mice. Hence, this new mouse model is a reliable and powerful tool to specifically study alpha-cells.Entities:
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Year: 2007 PMID： 17706201 DOI： 10.1016/j.febslet.2007.07.068
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124