Literature DB >> 17705291

Alpha-synuclein and its role in metal binding: relevance to Parkinson's disease.

Josephine A Wright1, David R Brown.   

Abstract

Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals. (c) 2007 Wiley-Liss, Inc.

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Year:  2008        PMID： 17705291     DOI： 10.1002/jnr.21461

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN： 0360-4012            Impact factor:   4.164


  12 in total

1.  EPR Methods for Biological Cu(II): L-Band CW and NARS.

Authors:  Brian Bennett; Jason M Kowalski
Journal:  Methods Enzymol       Date:  2015-07-23       Impact factor: 1.600

2.  Dissociation chemistry of hydrogen-deficient radical peptide anions.

Authors:  Benjamin Moore; Qingyu Sun; Julie C Hsu; Albert H Lee; Gene C Yoo; Tony Ly; Ryan R Julian
Journal:  J Am Soc Mass Spectrom       Date:  2011-12-30       Impact factor: 3.109

3.  Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism.

Authors:  Tomás R Guilarte; Neal C Burton; Jennifer L McGlothan; Tatyana Verina; Yun Zhou; Mohab Alexander; Luu Pham; Michael Griswold; Dean F Wong; Tore Syversen; Jay S Schneider
Journal:  J Neurochem       Date:  2008-09-20       Impact factor: 5.372

4.  Spin hamiltonian parameters for Cu(II)-prion peptide complexes from L-band electron paramagnetic resonance spectroscopy.

Authors:  Jason M Kowalski; Brian Bennett
Journal:  J Am Chem Soc       Date:  2011-01-25       Impact factor: 15.419

5.  Determine both the conformation and orientation of a specific residue in α-synuclein(61-95) even in monolayer by 13C isotopic label and p-polarized multiple-angle incidence resolution spectrometry (pMAIRS).

Authors:  Chengshan Wang; Yiqun Zhou; Christopher Ewuola; Toyin Akinleye; Takeshi Hasegawa; Roger M Leblanc
Journal:  Anal Sci       Date:  2022-05-28       Impact factor: 1.967

6.  Modulation of alpha-synuclein aggregation by dopamine analogs.

Authors:  Diane Latawiec; Fernando Herrera; Alpan Bek; Valeria Losasso; Michela Candotti; Federico Benetti; Elvio Carlino; Agata Kranjc; Marco Lazzarino; Stefano Gustincich; Paolo Carloni; Giuseppe Legname
Journal:  PLoS One       Date:  2010-02-16       Impact factor: 3.240

7.  Copper-triggered aggregation of ubiquitin.

Authors:  Fabio Arnesano; Simone Scintilla; Vincenza Calò; Elena Bonfrate; Chiara Ingrosso; Maurizio Losacco; Teresa Pellegrino; Enrico Rizzarelli; Giovanni Natile
Journal:  PLoS One       Date:  2009-09-16       Impact factor: 3.240

8.  The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.

Authors:  Saurabh Sen; Andrew B West
Journal:  Antioxid Redox Signal       Date:  2009-09       Impact factor: 8.401

9.  Protein-metal interactions of calmodulin and alpha-synuclein monitored by selective noncovalent adduct protein probing mass spectrometry.

Authors:  Tony Ly; Ryan R Julian
Journal:  J Am Soc Mass Spectrom       Date:  2008-07-16       Impact factor: 3.109

Review 10.  Metal imaging in neurodegenerative diseases.

Authors:  Megan W Bourassa; Lisa M Miller
Journal:  Metallomics       Date:  2012-07-16       Impact factor: 4.526
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