Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis.

Literature DB >> 17704817

An iron-sulfur domain of the eukaryotic primase is essential for RNA primer synthesis.

Sebastian Klinge¹, Judy Hirst, Joseph D Maman, Torsten Krude, Luca Pellegrini.

Abstract

Primases synthesize the RNA primers that are necessary for replication of the parental DNA strands. Here we report that the heterodimeric archaeal/eukaryotic primase is an iron-sulfur (Fe-S) protein. Binding of the Fe-S cluster is mediated by an evolutionarily conserved domain at the C terminus of the large subunit. We further show that the Fe-S domain is essential to the unique ability of the eukaryotic primase to start DNA replication.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17704817 PMCID： PMC2268749 DOI： 10.1038/nsmb1288

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

16 in total

1. Distinct domain functions regulating de novo DNA synthesis of thermostable DNA primase from hyperthermophile Pyrococcus horikoshii.

Authors: Eriko Matsui; Miho Nishio; Hideshi Yokoyama; Kazuaki Harata; Sophie Darnis; Ikuo Matsui
Journal: Biochemistry Date: 2003-12-23 Impact factor: 3.162

2. Mechanism of calf thymus DNA primase: slow initiation, rapid polymerization, and intelligent termination.

Authors: R J Sheaff; R D Kuchta
Journal: Biochemistry Date: 1993-03-30 Impact factor: 3.162

3. Yeast DNA primase and DNA polymerase activities. An analysis of RNA priming and its coupling to DNA synthesis.

Authors: H Singh; R G Brooke; M H Pausch; G T Williams; C Trainor; L B Dumas
Journal: J Biol Chem Date: 1986-06-25 Impact factor: 5.157

4. Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication.

Authors: W C Copeland; T S Wang
Journal: J Biol Chem Date: 1993-12-15 Impact factor: 5.157

5. A DNA primase activity associated with DNA polymerase alpha from Drosophila melanogaster embryos.

Authors: R C Conaway; I R Lehman
Journal: Proc Natl Acad Sci U S A Date: 1982-04 Impact factor: 11.205

6. The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting.

Authors: Laura K Zerbe; Robert D Kuchta
Journal: Biochemistry Date: 2002-04-16 Impact factor: 3.162

7. DNA primase activity from human lymphocytes. Synthesis of oligoribonucleotides that prime DNA synthesis.

Authors: B Y Tseng; C N Ahlem
Journal: J Biol Chem Date: 1982-07-10 Impact factor: 5.157

8. Affinity labeling of the active center and ribonucleoside triphosphate binding site of yeast DNA primase.

Authors: M Foiani; A J Lindner; G R Hartmann; G Lucchini; P Plevani
Journal: J Biol Chem Date: 1989-02-05 Impact factor: 5.157

9. A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae.

Authors: M Foiani; C Santocanale; P Plevani; G Lucchini
Journal: Mol Cell Biol Date: 1989-07 Impact factor: 4.272

10. Isolation of an intact DNA polymerase-primase from embryos of Drosophila melanogaster.

Authors: L S Kaguni; J M Rossignol; R C Conaway; I R Lehman
Journal: Proc Natl Acad Sci U S A Date: 1983-04 Impact factor: 11.205

101 in total

1. DNA charge transport as a first step in coordinating the detection of lesions by repair proteins.

Authors: Pamela A Sontz; Timothy P Mui; Jill O Fuss; John A Tainer; Jacqueline K Barton
Journal: Proc Natl Acad Sci U S A Date: 2012-01-23 Impact factor: 11.205

2. DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ.

Authors: Andrey G Baranovskiy; Artem G Lada; Hollie M Siebler; Yinbo Zhang; Youri I Pavlov; Tahir H Tahirov
Journal: J Biol Chem Date: 2012-03-30 Impact factor: 5.157

3. Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.

Authors: Sivaraja Vaithiyalingam; Eric M Warren; Brandt F Eichman; Walter J Chazin
Journal: Proc Natl Acad Sci U S A Date: 2010-07-19 Impact factor: 11.205

Review 4. Cytosolic iron-sulfur cluster assembly (CIA) system: factors, mechanism, and relevance to cellular iron regulation.

Authors: Anil K Sharma; Leif J Pallesen; Robert J Spang; William E Walden
Journal: J Biol Chem Date: 2010-06-03 Impact factor: 5.157

5. Insight into the Human DNA Primase Interaction with Template-Primer.

Authors: Andrey G Baranovskiy; Yinbo Zhang; Yoshiaki Suwa; Jianyou Gu; Nigar D Babayeva; Youri I Pavlov; Tahir H Tahirov
Journal: J Biol Chem Date: 2015-12-28 Impact factor: 5.157

6. Comment on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".

Authors: Andrey G Baranovskiy; Nigar D Babayeva; Yinbo Zhang; Luis Blanco; Youri I Pavlov; Tahir H Tahirov
Journal: Science Date: 2017-07-21 Impact factor: 47.728

7. Redox control of the DNA damage-inducible protein DinG helicase activity via its iron-sulfur cluster.

Authors: Binbin Ren; Xuewu Duan; Huangen Ding
Journal: J Biol Chem Date: 2008-12-12 Impact factor: 5.157

8. Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering.

Authors: Mairi Louise Kilkenny; Michael Anthony Longo; Rajika L Perera; Luca Pellegrini
Journal: Proc Natl Acad Sci U S A Date: 2013-09-16 Impact factor: 11.205

9. Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore.

Authors: Fan Zhang; Patrick Scheerer; Inga Oberpichler; Tilman Lamparter; Norbert Krauß
Journal: Proc Natl Acad Sci U S A Date: 2013-04-15 Impact factor: 11.205

10. Physical and functional interactions between uracil-DNA glycosylase and proliferating cell nuclear antigen from the euryarchaeon Pyrococcus furiosus.

Authors: Shinichi Kiyonari; Maiko Uchimura; Tsuyoshi Shirai; Yoshizumi Ishino
Journal: J Biol Chem Date: 2008-06-18 Impact factor: 5.157