BACKGROUND: Incomplete stent apposition (ISA) at follow-up has been reported to be more common after drug-eluting stent (DES) implantation than after bare-metal stent (BMS) implantation. The aim of this study was to use intravascular ultrasound (IVUS) to evaluate the coronary characteristics after drug-eluting stent implantation in patients with ISA at follow-up. METHODS: From the IVUS database of our institute, a total of 89 patients with 125 native lesions who underwent DES implantation into de novo lesions with IVUS imaging at 6-month follow-up were identified, and 15 (16.9%) patients had documented ISA at follow-up by IVUS. The ISA group was compared with a matched control group of patients (n = 30) who had no evidence of ISA at follow-up. RESULTS: Of the 15 documented ISA at follow-up after DES implantation, two located at the edge (within 5 mm from stent margin) while 13 in the body of the stent. The maximum area and arc of ISA measured 5.3 +/- 2.2 mm(2) and 163 +/- 67 degrees , respectively. In patients with ISA, the maximum EEM area of stent segment with ISA was significantly larger than the adjacent stent segment without ISA (24.1 +/- 3.3 vs. 20.1 +/- 3.1 mm(2), P = 0.002), while stent area, plaque plus media (P&M) area and intrastent lumen area were comparable (P > 0.05). Compared to the matched control cohort without ISA at follow-up, the maximum EEM area was also significantly larger (24.1 +/- 3.3 vs. 18.8 +/- 4.2 mm(2), P < 0.001), while the areas of reference EEM and lumen, stent, P&M behind the stent, intimal hyperplasia and intrastent lumen were all comparable between the two groups (P > 0.05). CONCLUSION: ISA at follow-up after DES implantation for de novo coronary lesions was associated with a larger EEM area.
BACKGROUND: Incomplete stent apposition (ISA) at follow-up has been reported to be more common after drug-eluting stent (DES) implantation than after bare-metal stent (BMS) implantation. The aim of this study was to use intravascular ultrasound (IVUS) to evaluate the coronary characteristics after drug-eluting stent implantation in patients with ISA at follow-up. METHODS: From the IVUS database of our institute, a total of 89 patients with 125 native lesions who underwent DES implantation into de novo lesions with IVUS imaging at 6-month follow-up were identified, and 15 (16.9%) patients had documented ISA at follow-up by IVUS. The ISA group was compared with a matched control group of patients (n = 30) who had no evidence of ISA at follow-up. RESULTS: Of the 15 documented ISA at follow-up after DES implantation, two located at the edge (within 5 mm from stent margin) while 13 in the body of the stent. The maximum area and arc of ISA measured 5.3 +/- 2.2 mm(2) and 163 +/- 67 degrees , respectively. In patients with ISA, the maximum EEM area of stent segment with ISA was significantly larger than the adjacent stent segment without ISA (24.1 +/- 3.3 vs. 20.1 +/- 3.1 mm(2), P = 0.002), while stent area, plaque plus media (P&M) area and intrastent lumen area were comparable (P > 0.05). Compared to the matched control cohort without ISA at follow-up, the maximum EEM area was also significantly larger (24.1 +/- 3.3 vs. 18.8 +/- 4.2 mm(2), P < 0.001), while the areas of reference EEM and lumen, stent, P&M behind the stent, intimal hyperplasia and intrastent lumen were all comparable between the two groups (P > 0.05). CONCLUSION: ISA at follow-up after DES implantation for de novo coronary lesions was associated with a larger EEM area.
Authors: G S Mintz; S E Nissen; W D Anderson; S R Bailey; R Erbel; P J Fitzgerald; F J Pinto; K Rosenfield; R J Siegel; E M Tuzcu; P G Yock Journal: J Am Coll Cardiol Date: 2001-04 Impact factor: 24.094
Authors: Kengo Tanabe; Patrick W Serruys; Muzaffer Degertekin; Giulio Guagliumi; Eberhard Grube; Charles Chan; Thomas Munzel; Jorge Belardi; Witold Ruzyllo; Luc Bilodeau; Henning Kelbaek; John Ormiston; Keith Dawkins; Louis Roy; Bradley H Strauss; Clemens Disco; Jörg Koglin; Mary E Russell; Antonio Colombo Journal: Circulation Date: 2003-12-22 Impact factor: 29.690
Authors: Pramod K Kuchulakanti; William W Chu; Rebecca Torguson; Patrick Ohlmann; Seung-Woon Rha; Leonardo C Clavijo; Sang-Wook Kim; Ahn Bui; Natalie Gevorkian; Zhenyi Xue; Kimberly Smith; Jana Fournadjieva; William O Suddath; Lowell F Satler; Augusto D Pichard; Kenneth M Kent; Ron Waksman Journal: Circulation Date: 2006-02-20 Impact factor: 29.690
Authors: Neil J Weissman; Joerg Koglin; David A Cox; James Hermiller; Charles O'Shaughnessy; James Tift Mann; Mark Turco; Ronald Caputo; Patrick Bergin; Joel Greenberg; Michael Kutcher; S Chiu Wong; Warren Strickland; Michael Mooney; Mary E Russell; Stephen G Ellis; Gregg W Stone Journal: J Am Coll Cardiol Date: 2005-04-19 Impact factor: 24.094
Authors: Andrew T L Ong; Angela Hoye; Jiro Aoki; Carlos A G van Mieghem; Gaston A Rodriguez Granillo; Karel Sonnenschein; Evelyn Regar; Eugene P McFadden; Georgios Sianos; Willem J van der Giessen; Peter P T de Jaegere; Pim de Feyter; Ron T van Domburg; Patrick W Serruys Journal: J Am Coll Cardiol Date: 2005-03-15 Impact factor: 24.094
Authors: J E Sousa; M A Costa; A C Abizaid; B J Rensing; A S Abizaid; L F Tanajura; K Kozuma; G Van Langenhove; A G Sousa; R Falotico; J Jaeger; J J Popma; P W Serruys Journal: Circulation Date: 2001-10-23 Impact factor: 29.690