Literature DB >> 17701149

Thymosin beta4 and Ac-SDKP: tools to mend a broken heart.

Alex Rossdeutsch1, Nicola Smart, Paul R Riley.   

Abstract

Thymosin beta4 - an endogenously occurring 43 amino acid peptide - has recently been shown to possess cardioprotective properties in the setting of acute myocardial infarction. This review focuses on the reported mechanisms of action through which Thymosin beta4 might accomplish this effect and the clinical prospects for its use as a therapeutic agent.

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Year:  2007        PMID： 17701149     DOI： 10.1007/s00109-007-0243-9

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  47 in total

1.  Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway.

Authors:  Todd C McDevitt; Michael A Laflamme; Charles E Murry
Journal:  J Mol Cell Cardiol       Date:  2005-10-19       Impact factor: 5.000

2.  In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction.

Authors:  R Morishita; T Sugimoto; M Aoki; I Kida; N Tomita; A Moriguchi; K Maeda; Y Sawa; Y Kaneda; J Higaki; T Ogihara
Journal:  Nat Med       Date:  1997-08       Impact factor: 53.440

3.  Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells.

Authors:  K M Malinda; A L Goldstein; H K Kleinman
Journal:  FASEB J       Date:  1997-05       Impact factor: 5.191

4.  Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids.

Authors:  J D Young; A J Lawrence; A G MacLean; B P Leung; I B McInnes; B Canas; D J Pappin; R D Stevenson
Journal:  Nat Med       Date:  1999-12       Impact factor: 53.440

5.  Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.

Authors:  Atsuhiko T Naito; Aki Tominaga; Masahito Oyamada; Yumiko Oyamada; Isao Shiraishi; Koshiro Monzen; Issei Komuro; Tetsuro Takamatsu
Journal:  Exp Cell Res       Date:  2003-11-15       Impact factor: 3.905

6.  Thymosin beta4 and thymosin beta4-derived peptides induce mast cell exocytosis.

Authors:  Janina Wyczółkowska; Aurelia Walczak-Drzewiecka; Waldemar Wagner; Jarosław Dastych
Journal:  Peptides       Date:  2007-01-13       Impact factor: 3.750

7.  Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction.

Authors:  Fang Yang; Xiao-Ping Yang; Yun-He Liu; Jiang Xu; Oscar Cingolani; Nour-Eddine Rhaleb; Oscar A Carretero
Journal:  Hypertension       Date:  2003-12-22       Impact factor: 10.190

8.  Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP.

Authors:  Maria A Cavasin; Nour-Eddine Rhaleb; Xiao-Ping Yang; Oscar A Carretero
Journal:  Hypertension       Date:  2004-03-22       Impact factor: 10.190

9.  Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable.

Authors:  D Safer; M Elzinga; V T Nachmias
Journal:  J Biol Chem       Date:  1991-03-05       Impact factor: 5.157

10.  Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.

Authors:  Nicola Smart; Catherine A Risebro; Athalie A D Melville; Kelvin Moses; Robert J Schwartz; Kenneth R Chien; Paul R Riley
Journal:  Nature       Date:  2006-11-15       Impact factor: 49.962
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  9 in total

Review 1.  Protein NMR in biomedical research.

Authors:  W Jahnke; H Widmer
Journal:  Cell Mol Life Sci       Date:  2004-02-26       Impact factor: 9.261

2.  Intrapericardial procedures for cardiac regeneration by stem cells: need for minimal invasive access (AttachLifter) to the normal pericardial cavity.

Authors:  H Rupp; T P Rupp; P Alter; N Jung; S Pankuweit; B Maisch
Journal:  Herz       Date:  2010-10       Impact factor: 1.443

3.  A Cell-Free SDKP-Conjugated Self-Assembling Peptide Hydrogel Sufficient for Improvement of Myocardial Infarction.

Authors:  Saman Firoozi; Sara Pahlavan; Mohammad-Hossein Ghanian; Shahram Rabbani; Shima Tavakol; Maryam Barekat; Saeed Yakhkeshi; Elena Mahmoudi; Mansoureh Soleymani; Hossein Baharvand
Journal:  Biomolecules       Date:  2020-01-30

Review 4.  The peptide network regulated by angiotensin converting enzyme (ACE) in hematopoiesis.

Authors:  Xiao Z Shen; Kenneth E Bernstein
Journal:  Cell Cycle       Date:  2011-05-01       Impact factor: 4.534

5.  Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.

Authors:  T T Myöhänen; J Tenorio-Laranga; B Jokinen; R Vázquez-Sánchez; M J Moreno-Baylach; J A García-Horsman; P T Männistö
Journal:  Br J Pharmacol       Date:  2011-08       Impact factor: 8.739

6.  Markers of progenitor cell recruitment and differentiation rise early during ischemia and continue during resuscitation in a porcine acute ischemia model.

Authors:  Atman P Shah; Scott T Youngquist; Christian D McClung; Ekaterina Tzvetkova; Mohammed A Hanif; John P Rosborough; James T Niemann
Journal:  J Interferon Cytokine Res       Date:  2011-02-20       Impact factor: 2.607

7.  Peptidomics of prolyl endopeptidase in the central nervous system.

Authors:  Whitney M Nolte; Debarati M Tagore; William S Lane; Alan Saghatelian
Journal:  Biochemistry       Date:  2009-12-22       Impact factor: 3.162

8.  Identification of Thymosin β4 as an effector of Hand1-mediated vascular development.

Authors:  Nicola Smart; Karina N Dubé; Paul R Riley
Journal:  Nat Commun       Date:  2010-07-27       Impact factor: 14.919

9.  A novel dimeric thymosin beta 4 with enhanced activities accelerates the rate of wound healing.

Authors:  Tian-Jiao Xu; Qi Wang; Xiao-Wen Ma; Zhen Zhang; Wei Zhang; Xiao-Chang Xue; Cun Zhang; Qiang Hao; Wei-Na Li; Ying-Qi Zhang; Meng Li
Journal:  Drug Des Devel Ther       Date:  2013-10-01       Impact factor: 4.162
  9 in total

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