Literature DB >> 15004697

Protein NMR in biomedical research.

W Jahnke1, H Widmer2.   

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a versatile biophysical technique with wide applicability in drug discovery research, particularly for the detection and characterization of molecular interactions. This review highlights in a comprehensive manner the aspects of biomolecular NMR which are most beneficial for pharmaceutical research and presents them as contributions to the different stages of a drug discovery program: target selection, assay development, lead generation and lead optimization. Emphasis is put on the concept of the particular NMR application, rather than on technical details, and on recent examples. Finally, an appendix of frequently asked questions is given.

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Year:  2004        PMID： 15004697     DOI： 10.1007/s00018-003-3382-3

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  62 in total

1.  Myocardial homing after intrapericardial infusion of bone marrow mononuclear cells.

Authors:  Erika Branco; Emerson Ticona Fioretto; Rosa Cabral; Carlos Alberto Sarmento Palmera; Guilherme Buzon Gregores; Angelo João Stopiglia; Paulo César Maiorka; Pedro Alves Lemos; Carlos Campos; Celso Takimura; José Antônio Franchini Ramires; Maria Angelica Miglino
Journal:  Arq Bras Cardiol       Date:  2009-09       Impact factor: 2.000

2.  The acute and long-term effects of intracoronary Stem cell Transplantation in 191 patients with chronic heARt failure: the STAR-heart study.

Authors:  Bodo-Eckehard Strauer; Muhammad Yousef; Christiana M Schannwell
Journal:  Eur J Heart Fail       Date:  2010-07       Impact factor: 15.534

3.  Cytokine activation in pericardial fluids in different forms of pericarditis.

Authors:  S Pankuweit; A Wädlich; E Meyer; I Portig; G Hufnagel; B Maisch
Journal:  Herz       Date:  2000-12       Impact factor: 1.443

4.  Mobilized bone marrow cells repair the infarcted heart, improving function and survival.

Authors:  D Orlic; J Kajstura; S Chimenti; F Limana; I Jakoniuk; F Quaini; B Nadal-Ginard; D M Bodine; A Leri; P Anversa
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-14       Impact factor: 11.205

5.  Myocardial infarction induces embryonic reprogramming of epicardial c-kit(+) cells: role of the pericardial fluid.

Authors:  Federica Limana; Chiara Bertolami; Antonella Mangoni; Anna Di Carlo; Daniele Avitabile; David Mocini; Pina Iannelli; Roberta De Mori; Carlo Marchetti; Ombretta Pozzoli; Carlo Gentili; Antonella Zacheo; Antonia Germani; Maurizio C Capogrossi
Journal:  J Mol Cell Cardiol       Date:  2009-12-05       Impact factor: 5.000

6.  Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias.

Authors:  M R Franz; R Cima; D Wang; D Profitt; R Kurz
Journal:  Circulation       Date:  1992-09       Impact factor: 29.690

7.  Identification of myocardial and vascular precursor cells in human and mouse epicardium.

Authors:  Federica Limana; Antonella Zacheo; David Mocini; Antonella Mangoni; Giovanna Borsellino; Adamo Diamantini; Roberta De Mori; Luca Battistini; Elisa Vigna; Massimo Santini; Vincenzo Loiaconi; Giulio Pompilio; Antonia Germani; Maurizio C Capogrossi
Journal:  Circ Res       Date:  2007-10-18       Impact factor: 17.367

8.  B-type natriuretic peptide and wall stress in dilated human heart.

Authors:  P Alter; H Rupp; M B Rominger; A Vollrath; F Czerny; J H Figiel; P Adams; F Stoll; K J Klose; B Maisch
Journal:  Mol Cell Biochem       Date:  2008-05-07       Impact factor: 3.396

9.  Relation of B-type natriuretic peptide to left ventricular wall stress as assessed by cardiac magnetic resonance imaging in patients with dilated cardiomyopathy.

Authors:  P Alter; H Rupp; M B Rominger; A Vollrath; F Czerny; K J Klose; B Maisch
Journal:  Can J Physiol Pharmacol       Date:  2007-08       Impact factor: 2.273

10.  Pericardial delivery of omega-3 fatty acid: a novel approach to reducing myocardial infarct sizes and arrhythmias.

Authors:  Yong-Fu Xiao; Daniel C Sigg; Michael R Ujhelyi; Joshua J Wilhelm; Eric S Richardson; Paul A Iaizzo
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-03-07       Impact factor: 4.733
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  12 in total

1.  NMR analysis reveals 17β-estradiol induced conformational change in ERβ ligand binding domain expressed in E. coli.

Authors:  Vijay Paramanik; M K Thakur
Journal:  Mol Biol Rep       Date:  2010-12-12       Impact factor: 2.316

2.  Determining the optimal size of small molecule mixtures for high throughput NMR screening.

Authors:  Kelly A Mercier; Robert Powers
Journal:  J Biomol NMR       Date:  2005-03       Impact factor: 2.835

3.  A 1H STD NMR spectroscopic investigation of sialylnucleoside mimetics as probes of CMP-Kdn synthetase.

Authors:  Thomas Haselhorst; Melanie Oschlies; Tareq Abu-Izneid; Milton J Kiefel; Joe Tiralongo; Anja K Münster-Kühnel; Rita Gerardy-Schahn; Mark von Itzstein
Journal:  Glycoconj J       Date:  2006-07       Impact factor: 2.916

4.  N-Acylated Derivatives of Sulfamethoxazole Block Chlamydia Fatty Acid Synthesis and Interact with FabF.

Authors:  Sergio A Mojica; Olli Salin; Robert J Bastidas; Naresh Sunduru; Mattias Hedenström; C David Andersson; Carlos Núñez-Otero; Patrik Engström; Raphael H Valdivia; Mikael Elofsson; Åsa Gylfe
Journal:  Antimicrob Agents Chemother       Date:  2017-09-22       Impact factor: 5.191

Review 5.  High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists.

Authors:  Bainan Wu; Elisa Barile; Surya K De; Jun Wei; Angela Purves; Maurizio Pellecchia
Journal:  Curr Top Med Chem       Date:  2015       Impact factor: 3.295

Review 6.  Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?

Authors:  Tomasz Cierpicki; Jolanta Grembecka
Journal:  Immunol Rev       Date:  2015-01       Impact factor: 12.988

Review 7.  High-field solution NMR spectroscopy as a tool for assessing protein interactions with small molecule ligands.

Authors:  Andria L Skinner; Jennifer S Laurence
Journal:  J Pharm Sci       Date:  2008-11       Impact factor: 3.534

8.  Perspectives of biomolecular NMR in drug discovery: the blessing and curse of versatility.

Authors:  Wolfgang Jahnke
Journal:  J Biomol NMR       Date:  2007-08-15       Impact factor: 2.582

9.  A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d.

Authors:  Elizabeth A Clark; Susan Crennell; Abhishek Upadhyay; Alexey V Zozulya; Julia D Mackay; Dmitri I Svergun; Stefan Bagby; Jean M H van den Elsen
Journal:  Mol Immunol       Date:  2010-11-04       Impact factor: 4.407

10.  Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.

Authors:  Jianming Zhang; Francisco J Adrián; Wolfgang Jahnke; Sandra W Cowan-Jacob; Allen G Li; Roxana E Iacob; Taebo Sim; John Powers; Christine Dierks; Fangxian Sun; Gui-Rong Guo; Qiang Ding; Barun Okram; Yongmun Choi; Amy Wojciechowski; Xianming Deng; Guoxun Liu; Gabriele Fendrich; André Strauss; Navratna Vajpai; Stephan Grzesiek; Tove Tuntland; Yi Liu; Badry Bursulaya; Mohammad Azam; Paul W Manley; John R Engen; George Q Daley; Markus Warmuth; Nathanael S Gray
Journal:  Nature       Date:  2010-01-13       Impact factor: 49.962
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