Literature DB >> 17700841

Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines.

Catherine J Smith1, Francisco Javier Iglesias-Sigüenza, Ian R Baxendale, Steven V Ley.   

Abstract

A new approach to the synthesis of 5-amino-4-cyanopyrazoles has been developed, utilising a novel flow microwave device. These products are then converted by a batch mode microwave process to structurally more complex dimeric and 'mixed' pyrazolopyrimidine structures.

Entities:  

Year:  2007        PMID： 17700841     DOI： 10.1039/b709043a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Authors:  Marcus Baumann; Ian R Baxendale; Steven V Ley
Journal:  Mol Divers       Date:  2010-10-20       Impact factor: 2.943

2.  Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.

Authors:  Alessandro Palmieri; Steven V Ley; Anastasios Polyzos; Mark Ladlow; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2009-05-20       Impact factor: 2.883

Review 3.  An overview of the synthetic routes to the best selling drugs containing 6-membered heterocycles.

Authors:  Marcus Baumann; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2013-10-30       Impact factor: 2.883

4.  A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process.

Authors:  Jian-Siang Poh; Duncan L Browne; Steven V Ley
Journal:  React Chem Eng       Date:  2016-01-07       Impact factor: 4.239

5.  Methyl glycosides via Fischer glycosylation: translation from batch microwave to continuous flow processing.

Authors:  Jonas Aronow; Christian Stanetty; Ian R Baxendale; Marko D Mihovilovic
Journal:  Monatsh Chem       Date:  2018-11-17       Impact factor: 1.451

Review 6.  Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications.

Authors:  Marek Trojanowicz
Journal:  Molecules       Date:  2020-03-21       Impact factor: 4.411
  6 in total

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