OBJECTIVES: To evaluate gadofosveset trisodium for first-pass magnetic resonance angiography (MRA) in the setting of whole-body MRA (WB-MRA). MATERIALS AND METHODS: Forty patients were examined using either 10 mL gadofosveset trisodium (n = 20) or 30 mL gadopentetate dimeglumine (n = 20), followed by arterial-phase imaging of 4 consecutive anatomic regions. Signal intensity was measured in 2 vessels per region. Relative contrast values (RC) were calculated. Arterial contrast, venous overlay, and image quality were rated by 2 radiologists. The Mann-Whitney U test was used to test for significance. RESULTS: Compared with gadopentetate dimeglumine, gadofosveset trisodium enhanced imaging revealed higher RC values in 2 vessel regions, with the differences being significant in 3 of 4 vessel segments. Gadofosveset trisodium revealed lower RC values in 2 regions with significant differences in 2 segments. Qualitative evaluation revealed higher ratings for gadofosveset trisodium regarding all 3 criteria with significant differences in 2 regions. CONCLUSIONS: Gadofosveset trisodium serves well for first-pass imaging in WB-MRA.
OBJECTIVES: To evaluate gadofosveset trisodium for first-pass magnetic resonance angiography (MRA) in the setting of whole-body MRA (WB-MRA). MATERIALS AND METHODS: Forty patients were examined using either 10 mL gadofosveset trisodium (n = 20) or 30 mL gadopentetate dimeglumine (n = 20), followed by arterial-phase imaging of 4 consecutive anatomic regions. Signal intensity was measured in 2 vessels per region. Relative contrast values (RC) were calculated. Arterial contrast, venous overlay, and image quality were rated by 2 radiologists. The Mann-Whitney U test was used to test for significance. RESULTS: Compared with gadopentetate dimeglumine, gadofosveset trisodium enhanced imaging revealed higher RC values in 2 vessel regions, with the differences being significant in 3 of 4 vessel segments. Gadofosveset trisodium revealed lower RC values in 2 regions with significant differences in 2 segments. Qualitative evaluation revealed higher ratings for gadofosveset trisodium regarding all 3 criteria with significant differences in 2 regions. CONCLUSIONS:Gadofosveset trisodium serves well for first-pass imaging in WB-MRA.
Authors: Johanna C Nissen; Ulrike I Attenberger; Christian Fink; Olaf Dietrich; Martin Rohrer; Stefan O Schoenberg; Henrik J Michaely Journal: Eur Radiol Date: 2009-03-13 Impact factor: 5.315
Authors: Harald Kramer; Val M Runge; John N Morelli; Kenneth D Williams; L Gill Naul; Konstantin Nikolaou; Maximilian F Reiser; Bernd J Wintersperger Journal: Eur Radiol Date: 2011-04-09 Impact factor: 5.315
Authors: A Napoli; M Anzidei; B Cavallo Marincola; F Zaccagna; D Geiger; P L Di Paolo; C Zini; C Catalano; R Passariello Journal: Radiol Med Date: 2009-05-06 Impact factor: 3.469