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Literature DB >> 11119550

Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models.

V Foulongne¹, K Walravens, G Bourg, M L Boschiroli, J Godfroid, M Ramuz, D O'Callaghan.

Abstract

The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in tissue culture (THP1 macrophages and HeLa cells) and murine virulence models.

Entities: Gene Species

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Year: 2001 PMID： 11119550 PMCID： PMC97916 DOI： 10.1128/IAI.69.1.547-550.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

26 in total

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