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Literature DB >> 17695221

Adenosine residues in the template do not block spontaneous replication steps of RNA.

Abstract

Sub-freezing temperatures, azabenzotriazolide activation, multiple monomer addition, and helper displacement help to overcome what seemed like an intrinsic block of adenine-templated RNA replication steps in the absence of enzymes.

Entities: Chemical

Mesh：

Substances：
RNA primers
RNA
Adenosine

Year: 2007 PMID： 17695221 DOI： 10.1039/b702768k

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

14 in total

Review 1. The origins of cellular life.

Authors: Jason P Schrum; Ting F Zhu; Jack W Szostak
Journal: Cold Spring Harb Perspect Biol Date: 2010-05-19 Impact factor: 10.005

2. Templating efficiency of naked DNA.

Authors: Eric Kervio; Annette Hochgesand; Ulrich E Steiner; Clemens Richert
Journal: Proc Natl Acad Sci U S A Date: 2010-06-16 Impact factor: 11.205

3. Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA.

Authors: Christopher Deck; Mario Jauker; Clemens Richert
Journal: Nat Chem Date: 2011-07-10 Impact factor: 24.427

4. The effect of leaving groups on binding and reactivity in enzyme-free copying of DNA and RNA.

Authors: Eric Kervio; Marilyne Sosson; Clemens Richert
Journal: Nucleic Acids Res Date: 2016-05-27 Impact factor: 16.971

5. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

Authors: Jason P Schrum; Alonso Ricardo; Mathangi Krishnamurthy; J Craig Blain; Jack W Szostak
Journal: J Am Chem Soc Date: 2009-10-14 Impact factor: 15.419

Adenosine residues in the template do not block spontaneous replication steps of RNA.

Review 1. The origins of cellular life.

2. Templating efficiency of naked DNA.

3. Efficient enzyme-free copying of all four nucleobases templated by immobilized RNA.

4. The effect of leaving groups on binding and reactivity in enzyme-free copying of DNA and RNA.

5. Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.

6. The strength of the template effect attracting nucleotides to naked DNA.

7. Sliding over the blocks in enzyme-free RNA copying--one-pot primer extension in ice.

Review 8. Synergism and mutualism in non-enzymatic RNA polymerization.

9. Copying of RNA Sequences without Pre-Activation.

10. Generation of functional RNAs from inactive oligonucleotide complexes by non-enzymatic primer extension.