OBJECTIVE: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis. METHODS: Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay. RESULTS: Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0 and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%. CONCLUSION: Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.
OBJECTIVE: To study roles of Clara cell protein 16 (CC16) and surfactant protein-D (SP-D) as serum biomarkers in the early diagnosis and the pathogenesis of silicosis. METHODS: Thirty healthy volunteers, 30 silica-exposed workers, and 30 workers with suspected silicosis and phase I silicosis were included. Serum CC16 and SP-D concentrations were determined using enzyme-linked immunosorbent assay. RESULTS: Serum CC16 concentrations decreased in silica-exposed workers when compared with in controls, but serum SP-D levels increased, and this trend was obvious in phase 0 and I groups. Discriminant analysis showed that the accuracies of classifying group membership into control, phase 0, phase 0, and phase I were 86.7%, 46.7%, 66.7%, and 70%, respectively, and the total classification accuracy rate was 67.5%. CONCLUSION: Serum CC16 and SP-D may be useful biomarkers for early diagnosis, and serum SP-D concentration may associate with the pathogenesis of silicosis.
Authors: Dag G Ellingsen; Bente Ulvestad; Berit Bakke; Ingebjørg Seljeflot; Lars Barregard; Yngvar Thomassen Journal: Int Arch Occup Environ Health Date: 2015-01-30 Impact factor: 3.015
Authors: Jeffrey J Atkinson; Barbara A Lutey; Yoko Suzuki; Holly M Toennies; Diane G Kelley; Dale K Kobayashi; Whitney G Ijem; Gaetan Deslee; Carla H Moore; M Eileen Jacobs; Susan H Conradi; David S Gierada; Richard A Pierce; Tomoko Betsuyaku; Robert M Senior Journal: Am J Respir Crit Care Med Date: 2010-11-05 Impact factor: 21.405