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Literature DB >> 17693503

Sequence analysis of the Staphylococcus aureus srrAB loci reveals that truncation of srrA affects growth and virulence factor expression.

Alexa A Pragman¹, Lisa Herron-Olson, Laura C Case, Sara M Vetter, Evan E Henke, Vivek Kapur, Patrick M Schlievert.

Abstract

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17693503 PMCID： PMC2168425 DOI： 10.1128/JB.00547-07

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

25 in total

1. Bias in phylogenetic estimation and its relevance to the choice between parsimony and likelihood methods.

Authors: D L Swofford; P J Waddell; J P Huelsenbeck; P G Foster; P O Lewis; J S Rogers
Journal: Syst Biol Date: 2001-08 Impact factor: 15.683

2. sarU, a sarA homolog, is repressed by SarT and regulates virulence genes in Staphylococcus aureus.

Authors: Adhar C Manna; Ambrose L Cheung
Journal: Infect Immun Date: 2003-01 Impact factor: 3.441

Review 3. Virulence regulation in Staphylococcus aureus: the need for in vivo analysis of virulence factor regulation.

Authors: Alexa A Pragman; Patrick M Schlievert
Journal: FEMS Immunol Med Microbiol Date: 2004-10-01

4. SarT, a repressor of alpha-hemolysin in Staphylococcus aureus.

Authors: K A Schmidt; A C Manna; S Gill; A L Cheung
Journal: Infect Immun Date: 2001-08 Impact factor: 3.441

5. Whole genome sequencing of meticillin-resistant Staphylococcus aureus.

Authors: M Kuroda; T Ohta; I Uchiyama; T Baba; H Yuzawa; I Kobayashi; L Cui; A Oguchi; K Aoki; Y Nagai; J Lian; T Ito; M Kanamori; H Matsumaru; A Maruyama; H Murakami; A Hosoyama; Y Mizutani-Ui; N K Takahashi; T Sawano; R Inoue; C Kaito; K Sekimizu; H Hirakawa; S Kuhara; S Goto; J Yabuzaki; M Kanehisa; A Yamashita; K Oshima; K Furuya; C Yoshino; T Shiba; M Hattori; N Ogasawara; H Hayashi; K Hiramatsu
Journal: Lancet Date: 2001-04-21 Impact factor: 79.321

6. Studies of the staphylococcal causation of toxic shock syndrome.

Authors: W A Altemeier; S Lewis; P M Schlievert; H S Bjornson
Journal: Surg Gynecol Obstet Date: 1981-10

7. Genome and virulence determinants of high virulence community-acquired MRSA.

Authors: Tadashi Baba; Fumihiko Takeuchi; Makoto Kuroda; Harumi Yuzawa; Ken-ichi Aoki; Akio Oguchi; Yoshimi Nagai; Natsuko Iwama; Kazuyuki Asano; Timothy Naimi; Hiroko Kuroda; Longzhu Cui; Kenji Yamamoto; Keiichi Hiramatsu
Journal: Lancet Date: 2002-05-25 Impact factor: 79.321

8. Characterization of virulence factor regulation by SrrAB, a two-component system in Staphylococcus aureus.

Authors: Alexa A Pragman; Jeremy M Yarwood; Timothy J Tripp; Patrick M Schlievert
Journal: J Bacteriol Date: 2004-04 Impact factor: 3.490

9. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.

Authors: Matthew T G Holden; Edward J Feil; Jodi A Lindsay; Sharon J Peacock; Nicholas P J Day; Mark C Enright; Tim J Foster; Catrin E Moore; Laurence Hurst; Rebecca Atkin; Andrew Barron; Nathalie Bason; Stephen D Bentley; Carol Chillingworth; Tracey Chillingworth; Carol Churcher; Louise Clark; Craig Corton; Ann Cronin; Jon Doggett; Linda Dowd; Theresa Feltwell; Zahra Hance; Barbara Harris; Heidi Hauser; Simon Holroyd; Kay Jagels; Keith D James; Nicola Lennard; Alexandra Line; Rebecca Mayes; Sharon Moule; Karen Mungall; Douglas Ormond; Michael A Quail; Ester Rabbinowitsch; Kim Rutherford; Mandy Sanders; Sarah Sharp; Mark Simmonds; Kim Stevens; Sally Whitehead; Bart G Barrell; Brian G Spratt; Julian Parkhill
Journal: Proc Natl Acad Sci U S A Date: 2004-06-22 Impact factor: 11.205

10. Identification of sarV (SA2062), a new transcriptional regulator, is repressed by SarA and MgrA (SA0641) and involved in the regulation of autolysis in Staphylococcus aureus.

Authors: Adhar C Manna; Susham S Ingavale; MaryBeth Maloney; Willem van Wamel; Ambrose L Cheung
Journal: J Bacteriol Date: 2004-08 Impact factor: 3.490

7 in total

1. Control of the Staphylococcus aureus toxic shock tst promoter by the global regulator SarA.

Authors: Diego O Andrey; Adriana Renzoni; Antoinette Monod; Daniel P Lew; Ambrose L Cheung; William L Kelley
Journal: J Bacteriol Date: 2010-09-24 Impact factor: 3.490

2. Staphylococcus epidermidis SrrAB regulates bacterial growth and biofilm formation differently under oxic and microaerobic conditions.

Authors: Youcong Wu; Yang Wu; Tao Zhu; Haiyan Han; Huayong Liu; Tao Xu; Patrice Francois; Adrien Fischer; Li Bai; Friedrich Götz; Di Qu
Journal: J Bacteriol Date: 2014-11-17 Impact factor: 3.490

Review 7. Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis.

Authors: Patrick M Schlievert; Kristi L Strandberg; Ying-Chi Lin; Marnie L Peterson; Donald Y M Leung
Journal: J Allergy Clin Immunol Date: 2010-01 Impact factor: 10.793