PURPOSE: Adjuvant, 5-fluorouracil (5-FU)-based chemoradiotherapy for completely resected high-risk gastric adenocarcinoma has been shown to improve survival in a randomized Intergroup trial. However, the results still showed an unsatisfactory outcome. On the basis of previously reported results of a Phase II trial using a more aggressive, cisplatin-containing chemoradiotherapy schedule, we investigated the effects of this approach on long-term renal function. PATIENTS AND METHODS: Between December 2000 and September 2003, 27 patients were treated at Tübingen University in a Phase II multicenter trial investigating adjuvant chemoradiotherapy. The adjuvant chemoradiotherapy consisted of two cycles of adjuvant 5-FU, folinic acid, cisplatin (200 mg/m2), and paclitaxel before and after radiotherapy (45 Gy in 1.8-Gy fractions) with daily concomitant 5-FU (225 mg/m2/24 h). A dose constraint of <or=12 Gy for 37.5% of the functional volume of both kidneys was used. Renal function was assessed by the changes in creatinine and creatinine clearance during follow-up. RESULTS: The prescribed 45 Gy was administered to 100% of the patients, and the cumulative cisplatin dose was 200 mg/m2 in 74% of all patients. In 89%, the constraints concerning the renal absorbed doses were met. The median follow-up for the creatinine and clearance values was 30 and 26 months, respectively. The creatinine values tended to worsen over time without reaching critical levels. We were unable to demonstrate a significant dose-response relationship for renal damage in the tested dose range. CONCLUSIONS: Using a dose constraint of <or=12 Gy for 37.5% of the functional volume of both kidneys appears to be safe at a median follow-up of 2 years for a cumulative cisplatin dose of 200 mg/m2 administered before and after simultaneous 5-FU and radiotherapy.
PURPOSE: Adjuvant, 5-fluorouracil (5-FU)-based chemoradiotherapy for completely resected high-risk gastric adenocarcinoma has been shown to improve survival in a randomized Intergroup trial. However, the results still showed an unsatisfactory outcome. On the basis of previously reported results of a Phase II trial using a more aggressive, cisplatin-containing chemoradiotherapy schedule, we investigated the effects of this approach on long-term renal function. PATIENTS AND METHODS: Between December 2000 and September 2003, 27 patients were treated at Tübingen University in a Phase II multicenter trial investigating adjuvant chemoradiotherapy. The adjuvant chemoradiotherapy consisted of two cycles of adjuvant 5-FU, folinic acid, cisplatin (200 mg/m2), and paclitaxel before and after radiotherapy (45 Gy in 1.8-Gy fractions) with daily concomitant 5-FU (225 mg/m2/24 h). A dose constraint of <or=12 Gy for 37.5% of the functional volume of both kidneys was used. Renal function was assessed by the changes in creatinine and creatinine clearance during follow-up. RESULTS: The prescribed 45 Gy was administered to 100% of the patients, and the cumulative cisplatin dose was 200 mg/m2 in 74% of all patients. In 89%, the constraints concerning the renal absorbed doses were met. The median follow-up for the creatinine and clearance values was 30 and 26 months, respectively. The creatinine values tended to worsen over time without reaching critical levels. We were unable to demonstrate a significant dose-response relationship for renal damage in the tested dose range. CONCLUSIONS: Using a dose constraint of <or=12 Gy for 37.5% of the functional volume of both kidneys appears to be safe at a median follow-up of 2 years for a cumulative cisplatin dose of 200 mg/m2 administered before and after simultaneous 5-FU and radiotherapy.
Authors: Kilian Salerno May; Gary Y Yang; Nikhil I Khushalani; Rameela Chandrasekhar; Gregory E Wilding; Leayn Flaherty; Harish K Malhotra; Richard C Russo; John C Warner; Johnny C Yap; Renuka V Iyer; Chukwumere E Nwogu; Saikrishna S Yendamuri; John F Gibbs; Hector R Nava; Dominick Lamonica; Charles R Thomas Journal: J Gastrointest Oncol Date: 2010-09
Authors: Stefan Haneder; Johannes Michael Budjan; Stefan Oswald Schoenberg; Simon Konstandin; Lothar Rudi Schad; Ralf Dieter Hofheinz; Veronika Gramlich; Frederik Wenz; Frank Lohr; Judit Boda-Heggemann Journal: Strahlenther Onkol Date: 2014-12-02 Impact factor: 3.621
Authors: Karin Oechsle; Carsten Bokemeyer; Jörg T Hartmann; Wilfried Budach; Tanja Trarbach; Michael Stahl; Ina Boehlke; Christian Kollmannsberger Journal: J Cancer Res Clin Oncol Date: 2008-09-30 Impact factor: 4.553
Authors: J Boda-Heggemann; C Weiss; V Schneider; R-D Hofheinz; S Haneder; H Michaely; H Wertz; U Ronellenfitsch; A Hochhaus; F Wenz; F Lohr Journal: Strahlenther Onkol Date: 2013-04-06 Impact factor: 3.621
Authors: S Haneder; H J Michaely; S O Schoenberg; S Konstandin; L R Schad; K Siebenlist; H Wertz; F Wenz; F Lohr; J Boda-Heggemann Journal: Strahlenther Onkol Date: 2012-11-01 Impact factor: 3.621
Authors: Daniel Buergy; Frank Lohr; Tobias Baack; Kerstin Siebenlist; Stefan Haneder; Henrik Michaely; Frederik Wenz; Judit Boda-Heggemann Journal: Radiat Oncol Date: 2012-11-16 Impact factor: 3.481