OBJECTIVE: The purpose of this article was to compare the effects of cod protein to those of other animal proteins on insulin sensitivity in insulin-resistant human subjects. RESEARCH DESIGN AND METHODS: Insulin sensitivity (M/I) was assessed using a hyperinsulinemic-euglycemic clamp in 19 insulin-resistant subjects fed a cod protein diet and a similar diet containing lean beef, pork, veal, eggs, milk, and milk products (BPVEM) for 4 weeks in a crossover design study. Both diets were formulated to differ only in protein source, thus providing equivalent amounts of dietary fibers and monounsaturated, polyunsaturated (including n-3), and saturated fatty acids (1.1:1.8:1.0). Beta-cell function, estimated by oral glucose tolerance test-derived parameters, was also assessed. RESULTS: There was a significant improvement in insulin sensitivity (P = 0.027) and a strong tendency for a better disposition index (beta-cell function xM/I) (P = 0.055) in subjects consuming the cod protein diet compared with those consuming the BPVEM diet. When median baseline M/I (4.8 x 10(-3) mg x kg(-1) x min(-1) x pmol(-1)) was taken into account, an interaction on the 30-min C-peptide-to-30-min glucose ratio, used as an index of beta-cell function, was observed between diet and M/I status (P = 0.022). Indeed, this ratio strongly tended to increase in subjects with low M/I consuming the cod protein diet compared with those consuming the BPVEM diet (P = 0.065). CONCLUSIONS:Dietary cod protein improves insulin sensitivity in insulin-resistant individuals and thus could contribute to prevention of type 2 diabetes by reducing the metabolic complications related to insulin resistance.
RCT Entities:
OBJECTIVE: The purpose of this article was to compare the effects of cod protein to those of other animal proteins on insulin sensitivity in insulin-resistant human subjects. RESEARCH DESIGN AND METHODS: Insulin sensitivity (M/I) was assessed using a hyperinsulinemic-euglycemic clamp in 19 insulin-resistant subjects fed a cod protein diet and a similar diet containing lean beef, pork, veal, eggs, milk, and milk products (BPVEM) for 4 weeks in a crossover design study. Both diets were formulated to differ only in protein source, thus providing equivalent amounts of dietary fibers and monounsaturated, polyunsaturated (including n-3), and saturated fatty acids (1.1:1.8:1.0). Beta-cell function, estimated by oral glucose tolerance test-derived parameters, was also assessed. RESULTS: There was a significant improvement in insulin sensitivity (P = 0.027) and a strong tendency for a better disposition index (beta-cell function x M/I) (P = 0.055) in subjects consuming the cod protein diet compared with those consuming the BPVEM diet. When median baseline M/I (4.8 x 10(-3) mg x kg(-1) x min(-1) x pmol(-1)) was taken into account, an interaction on the 30-min C-peptide-to-30-min glucose ratio, used as an index of beta-cell function, was observed between diet and M/I status (P = 0.022). Indeed, this ratio strongly tended to increase in subjects with low M/I consuming the cod protein diet compared with those consuming the BPVEM diet (P = 0.065). CONCLUSIONS: Dietary cod protein improves insulin sensitivity in insulin-resistant individuals and thus could contribute to prevention of type 2 diabetes by reducing the metabolic complications related to insulin resistance.
Authors: Pinal S Patel; Stephen J Sharp; Robert N Luben; Kay-Tee Khaw; Sheila A Bingham; Nicholas J Wareham; Nita G Forouhi Journal: Diabetes Care Date: 2009-07-10 Impact factor: 19.112
Authors: Diana P Brostow; Andrew O Odegaard; Woon-Puay Koh; Sue Duval; Myron D Gross; Jian-Min Yuan; Mark A Pereira Journal: Am J Clin Nutr Date: 2011-05-18 Impact factor: 7.045
Authors: Manas Kaushik; Dariush Mozaffarian; Donna Spiegelman; JoAnn E Manson; Walter C Willett; Frank B Hu Journal: Am J Clin Nutr Date: 2009-07-22 Impact factor: 7.045
Authors: Ida Heir Hovland; Ingrid Sande Leikanger; Oddbjørg Stokkeland; Kaia Hevrøy Waage; Svein A Mjøs; Karl A Brokstad; Adrian McCann; Per Magne Ueland; Rasa Slizyte; Ana Carvajal; Gunnar Mellgren; Tore Remman; Ingmar Høgøy; Oddrun A Gudbrandsen Journal: Eur J Nutr Date: 2019-04-10 Impact factor: 5.614