Literature DB >> 17681145

A balance of lipid-sensing mechanisms in the brain and liver.

Liora Caspi1, Penny Y T Wang, Tony K T Lam.   

Abstract

Recent work has cast a spotlight on the brain as a nutrient-sensing organ that regulates the body's metabolic processes. Here we discuss the physiological and molecular mechanisms of brain lipid sensing and compare these mechanisms to liver lipid sensing. A direct comparison between the lipid-sensing mechanisms in the brain and liver reveals similar biochemical/molecular but opposing physiological mechanisms in operation. We propose that an imbalance between the lipid-sensing mechanisms in the brain and liver may contribute to obesity-associated type 2 diabetes.

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Year:  2007        PMID： 17681145     DOI： 10.1016/j.cmet.2007.07.005

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  21 in total

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