PROBLEM: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? METHOD OF STUDY: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. RESULTS AND CONCLUSION: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
PROBLEM: Is the concept of maternal tolerance preventing rejection of the semi-allogeneic 'fetal allograft' still valid? METHOD OF STUDY: Compilation of expert reviews of literature and recent advances in research on indoleamine-2,3 dioxygenase (IDO), regulatory T cells and galectin-1. RESULTS AND CONCLUSION: A role for IDO in pregnancy success remains speculative, but solid data exist to support a role for Treg cells, and for galectin-1 in induction and action of Treg cells. Just as several signals may need to be simultaneously present to induce Th1 cytokine-triggered abortions, more than 1 signal may need to be simultaneously present to prevent rejection and ensure success. Both complement and coagulation pathways appear necessary for embryo execution.
Authors: JoonHo Lee; Roberto Romero; Yi Xu; Jung-Sun Kim; Ji Young Park; Juan Pedro Kusanovic; Tinnakorn Chaiworapongsa; Sonia S Hassan; Chong Jai Kim Journal: Am J Reprod Immunol Date: 2011-09-27 Impact factor: 3.886
Authors: Nandor Gabor Than; Roberto Romero; Morris Goodman; Amy Weckle; Jun Xing; Zhong Dong; Yi Xu; Federica Tarquini; Andras Szilagyi; Peter Gal; Zhuocheng Hou; Adi L Tarca; Chong Jai Kim; Jung-Sun Kim; Saied Haidarian; Monica Uddin; Hans Bohn; Kurt Benirschke; Joaquin Santolaya-Forgas; Lawrence I Grossman; Offer Erez; Sonia S Hassan; Peter Zavodszky; Zoltan Papp; Derek E Wildman Journal: Proc Natl Acad Sci U S A Date: 2009-06-02 Impact factor: 11.205
Authors: Rosanna Ramhorst; Laura Fraccaroli; Paulomi Aldo; Ayesha B Alvero; Ingrid Cardenas; Claudia Perez Leirós; Gil Mor Journal: Am J Reprod Immunol Date: 2011-08-07 Impact factor: 3.886
Authors: Nandor Gabor Than; Roberto Romero; Offer Erez; Amy Weckle; Adi L Tarca; John Hotra; Asad Abbas; Yu Mi Han; Sung-Su Kim; Juan Pedro Kusanovic; Francesca Gotsch; Zhuocheng Hou; Joaquin Santolaya-Forgas; Kurt Benirschke; Zoltan Papp; Lawrence I Grossman; Morris Goodman; Derek E Wildman Journal: Proc Natl Acad Sci U S A Date: 2008-09-29 Impact factor: 11.205