PURPOSE: In human epidermal growth factor 2 (HER-2)-positive advanced breast cancer, taxanes or vinorelbine plus trastuzumab are among the most widely applied options in the first-line setting. We evaluated the efficacy and tolerability of capecitabine plus trastuzumab after anthracycline and docetaxel or vinorelbine failure and prior trastuzumab exposure. PATIENTS AND METHODS: Forty consecutive patients were included. Capecitabine was administered at a dose of 1,250 mg/m(2) bid for 14 consecutive days in 3-week cycles, with dose modifications if necessary. Trastuzumab was administered every 3 weeks. Time to progression (TTP) was defined as primary end point. Response was evaluated every 3 months using International Union Against Cancer criteria. RESULTS: TTP was a median of 8 months, and overall survival was 24 months. No significant difference was found for second-line and beyond second-line treatment. A complete response (CR) was observed in 2.5%, partial response (PR) in 17.5%, stable disease lasting at least 6 months (SD) in 50%, resulting in a clinical benefit rate (CR + PR + SD > or = 6 months) of 70%. Diarrhea (5%) and hand-foot syndrome (15%) were the only treatment-related adverse events that occurred with grade 3 or 4 intensity. Three patients (7.5%) developed brain metastases while receiving therapy. CONCLUSION: Capecitabine plus trastuzumab appears to be an effective and safe option in a heavily pretreated population. Therefore, a direct comparison of this regimen with capecitabine monotherapy in this setting is warranted.
PURPOSE: In human epidermal growth factor 2 (HER-2)-positive advanced breast cancer, taxanes or vinorelbine plus trastuzumab are among the most widely applied options in the first-line setting. We evaluated the efficacy and tolerability of capecitabine plus trastuzumab after anthracycline and docetaxel or vinorelbine failure and prior trastuzumab exposure. PATIENTS AND METHODS: Forty consecutive patients were included. Capecitabine was administered at a dose of 1,250 mg/m(2) bid for 14 consecutive days in 3-week cycles, with dose modifications if necessary. Trastuzumab was administered every 3 weeks. Time to progression (TTP) was defined as primary end point. Response was evaluated every 3 months using International Union Against Cancer criteria. RESULTS: TTP was a median of 8 months, and overall survival was 24 months. No significant difference was found for second-line and beyond second-line treatment. A complete response (CR) was observed in 2.5%, partial response (PR) in 17.5%, stable disease lasting at least 6 months (SD) in 50%, resulting in a clinical benefit rate (CR + PR + SD > or = 6 months) of 70%. Diarrhea (5%) and hand-foot syndrome (15%) were the only treatment-related adverse events that occurred with grade 3 or 4 intensity. Three patients (7.5%) developed brain metastases while receiving therapy. CONCLUSION:Capecitabine plus trastuzumab appears to be an effective and safe option in a heavily pretreated population. Therefore, a direct comparison of this regimen with capecitabine monotherapy in this setting is warranted.
Authors: Winston W Tan; Jacob B Allred; Muhammad Salim; Patrick Flynn; Paul A S Fishkin; Philip J Stella; Martin Wiesenfeld; Albert M Bernath; Tom R Fitch; Edith A Perez Journal: Clin Breast Cancer Date: 2012-04 Impact factor: 3.225
Authors: Rupert Bartsch; Catharina De Vries; Ursula Pluschnig; Peter Dubsky; Zsuzsanna Bago-Horvath; Simon P Gampenrieder; Margaretha Rudas; Robert M Mader; Andrea Rottenfusser; Christoph Wiltschke; Michael Gnant; Christoph C Zielinski; Guenther G Steger Journal: BMC Cancer Date: 2009-10-17 Impact factor: 4.430
Authors: S Dent; Sh Verma; J Latreille; D Rayson; M Clemons; J Mackey; Su Verma; J Lemieux; L Provencher; S Chia; B Wang; K Pritchard Journal: Curr Oncol Date: 2009-08 Impact factor: 3.677