Literature DB >> 17676848

A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier.

Wing-Yin Tsang1, John P Richard.   

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Year:  2007        PMID： 17676848      PMCID： PMC2543129          DOI： 10.1021/ja073679g

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  2 in total

1.  Formation and stability of enolates of acetamide and acetate anion: an Eigen plot for proton transfer at alpha-carbonyl carbon.

Authors:  John P Richard; Glenn Williams; AnnMarie C O'Donoghue; Tina L Amyes
Journal:  J Am Chem Soc       Date:  2002-03-27       Impact factor: 15.419

2.  A Marcus treatment of rate constants for protonation of ring-substituted alpha-methoxystyrenes: intrinsic reaction barriers and the shape of the reaction coordinate.

Authors:  John P Richard; Kathleen B Williams
Journal:  J Am Chem Soc       Date:  2007-05-09       Impact factor: 15.419
  2 in total
  7 in total

1.  Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate.

Authors:  Krisztina Toth; Tina L Amyes; Bryant M Wood; Kui Chan; John A Gerlt; John P Richard
Journal:  J Am Chem Soc       Date:  2010-05-26       Impact factor: 15.419

2.  An automated integration-free path-integral method based on Kleinert's variational perturbation theory.

Authors:  Kin-Yiu Wong; Jiali Gao
Journal:  J Chem Phys       Date:  2007-12-07       Impact factor: 3.488

3.  Proton transfer from C-6 of uridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase: formation and stability of a vinyl carbanion intermediate and the effect of a 5-fluoro substituent.

Authors:  Wing-Yin Tsang; B McKay Wood; Freeman M Wong; Weiming Wu; John A Gerlt; Tina L Amyes; John P Richard
Journal:  J Am Chem Soc       Date:  2012-08-21       Impact factor: 15.419

4.  Primary Deuterium Kinetic Isotope Effects From Product Yields: Rationale, Implementation, and Interpretation.

Authors:  Tina L Amyes; John P Richard
Journal:  Methods Enzymol       Date:  2017-08-23       Impact factor: 1.600

5.  Structure-reactivity effects on primary deuterium isotope effects on protonation of ring-substituted alpha-methoxystyrenes.

Authors:  Wing-Yin Tsang; John P Richard
Journal:  J Am Chem Soc       Date:  2009-10-07       Impact factor: 15.419

6.  Theoretical analysis of kinetic isotope effects on proton transfer reactions between substituted alpha-methoxystyrenes and substituted acetic acids.

Authors:  Kin-Yiu Wong; John P Richard; Jiali Gao
Journal:  J Am Chem Soc       Date:  2009-10-07       Impact factor: 15.419

7.  Enzymatic Catalysis of Proton Transfer and Decarboxylation Reactions.

Authors:  John P Richard
Journal:  Pure Appl Chem       Date:  2011-07-08       Impact factor: 2.453
  7 in total

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