AIMS: The aim of this study was to investigate the change in plasma brain natriuretic peptide (BNP) level after pulmonary vein isolation (PVI) in paroxysmal (PAF), persistent (Pers-AF), and permanent atrial fibrillation (AF) (Perm-AF) patients. METHODS AND RESULTS: In 96 lone AF patients (PAF=65, Pers-AF=17, and Perm-AF=14), BNP was measured before and 3 months after successful PVIs. At baseline, in all patients, BNP was elevated and was significantly greater in Pers-AF and Perm-AF patients than PAF patients (P<0.05). After 3 months of follow-up following multiple PVIs, AF recurred in 12 (18%) PAF, 7 (41%) Pers-AF, and 8 (57%) Perm-AF patients. In Pers-AF and Perm-AF patients, BNP at baseline did not predict AF recurrence. After the PVIs, BNP significantly decreased in PAF and Pers-AF patients (P=0.005) but not in Perm-AF patients. An elevated BNP at baseline decreased to within-normal limits in all Pers-AF and Perm-AF patients without AF recurrences. In all seven (23%) patients, whose AF type improved after the PVIs, BNP decreased. CONCLUSION: The reduction in the BNP level after the PVI seemed to be a marker for a good outcome in AF post-ablation patients.
AIMS: The aim of this study was to investigate the change in plasma brain natriuretic peptide (BNP) level after pulmonary vein isolation (PVI) in paroxysmal (PAF), persistent (Pers-AF), and permanent atrial fibrillation (AF) (Perm-AF) patients. METHODS AND RESULTS: In 96 lone AFpatients (PAF=65, Pers-AF=17, and Perm-AF=14), BNP was measured before and 3 months after successful PVIs. At baseline, in all patients, BNP was elevated and was significantly greater in Pers-AF and Perm-AFpatients than PAFpatients (P<0.05). After 3 months of follow-up following multiple PVIs, AF recurred in 12 (18%) PAF, 7 (41%) Pers-AF, and 8 (57%) Perm-AFpatients. In Pers-AF and Perm-AFpatients, BNP at baseline did not predict AF recurrence. After the PVIs, BNP significantly decreased in PAF and Pers-AFpatients (P=0.005) but not in Perm-AFpatients. An elevated BNP at baseline decreased to within-normal limits in all Pers-AF and Perm-AFpatients without AF recurrences. In all seven (23%) patients, whose AF type improved after the PVIs, BNP decreased. CONCLUSION: The reduction in the BNP level after the PVI seemed to be a marker for a good outcome in AF post-ablation patients.
Authors: Thomas Deneke; Anja Schade; Joachim Krug; Karsten Stahl; Geza Atilla Szollosi; Dong In Shin; Clemens Nino Schukro; Mohamed El Tarahony; Enrique Murillo; Semko Aram; Gabriele Robhirt; Thomas Lawo; Andreas Mugge; Peter H Grewe; Sebastian Kerber Journal: J Atr Fibrillation Date: 2012-02-02
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