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Literature DB >> 17667894

Antifungal potential of disulfiram.

Seema Khan¹, Smita Singhal, Tarun Mathur, Dilip J Upadhyay, Ashok Rattan.

Abstract

Disulfiram, an alcohol antagonistic drug has been on the market since 1949 with 80% bioavailability and an established safety profile. Recently it has been reported as a P-glycoprotein efflux pump modulator. Herein we report its antifungal potential. The MIC50 and MIC90 of disulfiram for yeast isolates is 4 and 8 microg/ml, respectively, and the MIC range is 1-16 micro g/ml for both fluconazole sensitive and resistant strains. Interestingly, disulfiram also showed fungicidal activity on Aspergillus spp. with MIC50 and MIC90 of 2 and 8 microg/ml, respectively.

Entities: Chemical Species

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Year: 2007 PMID： 17667894 DOI： 10.3314/jjmm.48.109

Source DB: PubMed Journal: Nihon Ishinkin Gakkai Zasshi ISSN： 0916-4804

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Cited

11 in total

1. Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.

Authors: Emina Jukic; Michael Blatzer; Wilfried Posch; Marion Steger; Ulrike Binder; Cornelia Lass-Flörl; Doris Wilflingseder
Journal: Antimicrob Agents Chemother Date: 2017-09-22 Impact factor: 5.191

2. Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner.

Authors: Alex G Dalecki; Mehri Haeili; Santosh Shah; Alexander Speer; Michael Niederweis; Olaf Kutsch; Frank Wolschendorf
Journal: Antimicrob Agents Chemother Date: 2015-06-01 Impact factor: 5.191

3. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.

Authors: Ann R Holmes; Mikhail V Keniya; Irena Ivnitski-Steele; Brian C Monk; Erwin Lamping; Larry A Sklar; Richard D Cannon
Journal: Antimicrob Agents Chemother Date: 2011-12-27 Impact factor: 5.191

4. Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

Authors: Yasuhiro Horita; Takemasa Takii; Tetsuya Yagi; Kenji Ogawa; Nagatoshi Fujiwara; Emi Inagaki; Laurent Kremer; Yasuo Sato; Ryuji Kuroishi; Yoosa Lee; Toshiaki Makino; Hajime Mizukami; Tomohiro Hasegawa; Ryuji Yamamoto; Kikuo Onozaki
Journal: Antimicrob Agents Chemother Date: 2012-05-21 Impact factor: 5.191

Review 10. Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi.

Authors: Lucie Peyclit; Hanane Yousfi; Jean-Marc Rolain; Fadi Bittar
Journal: Pharmaceuticals (Basel) Date: 2021-05-20

Antifungal potential of disulfiram.

1. Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.

2. Disulfiram and Copper Ions Kill Mycobacterium tuberculosis in a Synergistic Manner.

3. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates.

4. Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.

5. Repurposing of Ribavirin as an Adjunct Therapy against Invasive Candida Strains in an In Vitro Study.

6. Effect of copper on the antifungal activity of disulfiram (Antabuse®) in fluconazole-resistant Candida strains.

7. Disulfiram: A Repurposed Drug in Preclinical and Clinical Development for the Treatment of Infectious Diseases.

8. Antifungal application of nonantifungal drugs.

9. A Unique Dual-Readout High-Throughput Screening Assay To Identify Antifungal Compounds with Aspergillus fumigatus.

Review 10. Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi.