| Literature DB >> 17665953 |
Kuan-Hon Lim1, Osamu Hiraku, Kanki Komiyama, Takashi Koyano, Masahiko Hayashi, Toh-Seok Kam.
Abstract
Nine new indole alkaloids, rhazinoline (1), 19(S)-methoxytubotaiwine (2), 19(R)-methoxytubotaiwine (3), kopsamidine A (4), kopsamidine B (5), kopsinidine A (6), kopsinidine B (7), paucidactine C (8), and pericine N-oxide (9), in addition to several recently reported novel indoles and 34 other known ones, were obtained from the stem-bark extract of the Malayan Kopsia arborea. The structures were determined using NMR and MS analysis. Valparicine (12) showed pronounced cytotoxic effects against KB and Jurkat cells (IC(50) 13.0 and 0.91 microM, respectively).Entities:
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Year: 2007 PMID： 17665953 DOI： 10.1021/np0702234
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050